Development of Curcuma longa Extract Gel for Periodontal Treatment
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Abstract
Periodontal diseases are inflammatory conditions affecting the tissue surrounding the teeth. Turmeric (Curcuma longa L.) is a well-known Thai herb, whose active substances are essential oils and curcuminoids. Many studies have shown that turmeric has anti-inflammatory, anti-oxidant and anti-bacterial properties. This study aimed to develop the formulation of C. longa ethanolic extract gel for use as a local delivery system for periodontal treatment. The amounts of curcuminoids in C. longa ethanolic crude extract were analyzed using high-performance liquid chromatography (HPLC). The formulations containing 1–2% of crude extract were prepared. Carbopol 934P was used as a gelling agent. The physical appearance, pH, viscosity, syringeability, and stability after centrifugal test were evaluated. The selected formula was assessed for accelerated condition stability and analyzed for the amount of curcuminoids in the gel with the HPLC. The results showed that C. longa crude extract contained curcuminoids, 16.582 ± 0.570% w/w, including curcumin, demethoxycurcumin and bisdemethoxycurcumin. F1 gel formulation was selected as the best formula. The formulation consisted of 1% turmeric crude extract and 1% carbopol 934P as a gelling agent. The physical appearance especially homogeneity of the gel was good; its pH value was 7.03 ± 0.04; and its viscosity was 9,660.00 ± 693.11 cP at 100 rpm. The selected formulation containing three curcuminoids had ease of syringeability through a 21 gauge needle and good stability after six heating-cooling test cycles. In conclusion, the C. longa extract gel formulation has good physiochemical characteristics and good stability which can be used as an alternative remedy for periodontal treatment.
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