Short Communication on Use of Andrographis Herb (FA THALAI CHON) for the Treatment of COVID-19 Patients.

Main Article Content

Amporn Benjaponpithak
Khwanchai Visithanon
Thiti Sawaengtham
Tewan Thaneerat
Kulthanit Wanaratna




Download data is not yet available.

Article Details

Journal Club


Sawadeemongkol K, Permpipat U, Kiatyingingangsulee N, et al. Pharmacological studies of Andrographis

paniculate Wall.Ex Nees. Meeting Report of Andrographis paniculate Wall. Ex Nees. Department of Medical

Sciences. 1990.

Limpanishgul S. The study of anti-inflammatory activity of medicinal plant, Andrographis paniculata nees in

rats (thesis). Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University; 1989.

Rattanasothorn N, Polachart P. Anti-inflammatory activity of Andrographis paniculata Wall.Ex Nees in mice.

Special program of Faculty of Pharmaceutical, Mahidol University; 2006.

Deng W, Nie R, Liu J. Comparison of pharmacological effect of four andrographolides. Yao Hsueh T’ung Pao.


Madav S, Tandan SK, Lal J, et al. Anti-inflammatory activity of andrographolide. Fitoterapia. 1996;67(5):452-8.

Thamaree S, Rugrungtham K, Ruangrungsi N, Thaworn N, Kemsri W. The inhibitory effects of extracts of some

herbal medicines on the production of proinflammatory cytokines by in vitro stimulated human blood cells. Thai

J Pharm Sci. 1998;22(3):S47.

Chiou WF, Chen CF, Lin JJ. Mechanisms of supression of inducible nitric oxide synthase (iNOS) expression in

RAW 264.7 cells by andrographolide. Br J Pharmacol. 2000;129(8):1553-60.

Thamaree S, Rugrungtham K, Ruangrungsi N,Thaworn N, Kemsri W. The inhibitory effects of andrographolide

and extracts of some herbal medicines on the production of proinflammatory cytokines by LPS-stimulated human blood cells. Chula Med J. 2001;45(8):661-70.

Shen YC, Chen CF, Chiou WF. Supression of rat neutrophil reactive oxygen species production and adhesion

by the diterpenoid lactone andrographolide. Planta Med. 2000;66:314-7.

Shen YC, Chen CF, Chiou WF. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Br J Pharmacol. 2002;135(2):399-406.

Batkhuu J, Hattori K, Takano F, Fushiya S, Oshiman K, Fujimiya Y. Suppression of NO production in activated

macrophages in vitro and ex vivo by neoandrographolide isolated from Andrographis paniculata. Biol Pharm Bull. 2002;25(9):1169-74.

Hsu LW, Chang SC, Shen CH, Chuang KS. Andrographolide and its derivatives as TNF-alpha antagonists.

Patent: US Pat Appl Publ US. 2006106098, 22. 2006.

Qin LH, Kong L, Shi GJ, Wang ZT, Ge BX. Andrographolide inhibits the production of TNF-alpha and interleukin-12 in lipopolysaccharide-stimulated macrophages: role of mitogen-activated protein kinases. Biol Pharm Bull. 2006.29(2):220-4.

Liu J, Wang ZT, Ge BX. Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory

property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling

pathways. Int Immunopharmacol. 2008;8:951-8.

Sulaiman MR, Zakaria ZA, Abdul Rahman A, Mohamad AS, Desa MN, Stanslas J, Moin S, Israf DA. Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models. Biol Res Nurs. 2010;11(3):293-301.

Madav S, Tripathi HC, Tandan MSK. Analgesic, antipyretic and antiulcerogenic effects of andrographolide.

Indian J Pharm Sci. 1995;57(3):121-5.

Nosálová G, Majee SK, Ghosh K, Raja W, Chatterjee UR, Jureček L, Ray B. Antitussive arabinogalactan of Andrographis paniculata demonstrates synergistic effect with andrographolide. Int J Biol Macromol. 2014;69:151-7.

Rajagopal S, Ajaya Kumar R, Deevi DS, Satyanarayana C, Rajagopalan R. Andrographolide, a potential cancer

therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol. 2003;3:147-58.

Xu Y, Chen A, Fry S, Barrow RA, Marshall RL, Mukkur TKS. Modulation of immune response in mice immunized

with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide. Int Immunopharmacol. 2007;7:515-23.

Cai W, Li Y, Chen S, Wang M, Zhang A, Zhou H, Chen H, Jin M. 14-Deoxy-11,12-dehydroandrographolide

exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export

of viral ribonucleoprotein complexes. Antiviral Res. 2015;118:82-92.

Cai W, Chen S, Li Y, Zhang A, Zhou H, Chen H, Jin M. 14-Deoxy-11,12-didehydroandrographolide attenuates

excessive inflammatory responses and protects mice lethally challenged with highly pathogenic A(H5N1)

influenza viruses. Antiviral Res. 2016;133:95-105.

Chen JX, Xue HJ, Ye WC, Fang BH, Liu YH, Yuan SH, Yu P, Wang YQ. Activity of andrographolide and its

derivatives against influenza virus in vivo and in vitro. Biol Pharm Bull. 2009;32(8):1385-91.

Churiyah, Pongtuluran OB, Rofaani E, Tarwadi. Antiviral and immunostimulant activities of Andrographis

paniculata. HAYATI J Biosci. 2015;22(2):67-72.

Ding Y, Chen L, Wu W, Yang J, Yang Z, Liu S. Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-kB and JAK-STAT signaling pathway. Microbes Infect. 2017;19(12):605-15.

Edwin ES, Vasantha-Srinivasan P, Senthil-Nathan S, Thanigaivel A, Ponsankar A, Pradeepa V, Selin-Rani S,

Kalaivani K, Hunter WB, Abdel-Megeed A, Duraipandiyan V, Al-Dhabi NA. Anti-dengue efficacy of bioactive

andrographolide from Andrographis paniculata (Lamiales: Acanthaceae) against the primary dengue vector Aedes aegypti (Diptera: Culicidae). Acta Trop. 2016;163:167-78.

Gupta B, Mishra KP, Ganju L. 2017. Broad-spectrum antiviral properties of andrographolide. Arch Virol.

;162(3): 611-23.

Caceres DD, Hancke JL, Burgos RA, Wikman GK. Prevention of common colds with Andrographis paniculata

dried extract. A pilot double blind trial. Phytomedicine. 1997;4(2):101-4.

Hancke J, Burgos R, Caceres D, Wikman G. A doubleblind study with a new monodrug Kan Jang: decrease

of symptoms and improvement in the recovery from common colds. Phytother Res. 1995;9:559-62.

Saxena RC, Singh R, Kumar P, Yadav SC, Negi MPS, Saxena VS, Amit A. A randomized double blind placebo

controlled clinical evaluation of extract of Andrographis paniculata (KalmCold™) in patients with uncomplicated upper respiratory tract infection. Phytomedicine. 2010;17(3-4):178-85

Bhuiyam FR, Howlader S, Raihan T, Hasan M. Plants metabolites: Possibility of natural therapeutics against the COVID-19 pandemic. Front Med (Lausanne). 2020;7:444.

Enmozhi SK, Raja K, Sebastine I, Joseph J. Andrographolide as a potential inhibitor of SARS-CoV-2 main

protease: An in silico approach. J Biomolec Struc Dyn. 2020. (DOI: 10.1080/07391102.2020.1760136)

Mohammad T, Shamsi A, Anwar S, Umair M, Hussain A, Rehman MT, AlAjmi MF, Islam A, Hassan MI.

Identification of high-affinity inhibitors of SARS-CoV-2 main protease: Towards the development of effective

COVID-19 therapy. Virus Res. 2020;288:198102.

Shi TZ, Huang YL, Chen CC, Pi WC, Hsu YL, Lo LC, Chen WY, Fu SL, Lin CH. Andrographolide and its fluorescent

derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage. Biochem Biophys

Res Commun. 2020;533(3):67–473.

Maurya VK, Kumar S, Prasad AK, Bhatt MLB, Saxena SK. Structure-based drug designing for potential antiviral

activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular

receptor. VirusDisease. 2020;31:179-93.

Murugan NA, Pandian CJ, Jeyakanthan J. Computational investigation on Andrographis paniculata phytochemicals to evaluate their potency against SARS-CoV-2 in comparison to known antiviral compounds in drug trials. J Biomol Struct Dyn. 2020. (DOI: 10.1080/07391102.2020.1777901)

Most read articles by the same author(s)