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In the past, the consumption of cannabis for any purpose was prohibited by law in Thailand; thus, there was no research on the efficacy and safety of cannabis conducted by Thai researchers. However, in 2019, Thailand began to legalize cannabis for medical treatment and research. Lampang Hospital is one of the hospitals in the country that has set up a medical cannabis clinic. The cannabis extract used in our clinic is GPO THC oil 0.5 mg/drop. The objective of this research was to determine the clinical outcomes of patients after receiving cannabis extract. It was a time series study collecting prospective data on patients visiting the Medical Cannabis Clinic at Lampang Hospital from 28 August 2019 to 30 June 2020. The quality of life scores measured by EQ-5D-5L questionnaire and pain scores were collected and compared at each clinic visit using repeated measure ANOVA and Friedman test. The results showed that, among a total of 85 patients participating in this study, the mean age was 59.4 ± 12 years; 54% were male and 41% had received cannabis prior to their visit to the clinic. The common purposes of using cannabis extract were for palliative treatment (53%) and relieving pain (40%), migraine (4%), insomnia (2%), and nausea/vomiting from chemotherapy (1%). A total of 50 patients were followed up for 10 visits. For the efficacy, the median quality of life score significantly increased [0.016 (-0.131, 0.279); -0.283-0.960 vs 0.132(-0.204,0.703); -0.204-0.703,P < 0.001] and the mean pain score significantly decreased (8.24±2.3vs5.00±2.0, P < 0.001). For safety, 9 patients (10.6%) hadside effects from cannabis when Naranjo’salgorithm wasused; 3 of whom had to discontinue cannabis due to cannabis-induced psychosis, disorientation, and abnormal blood pressure, and 6 were able to continue cannabis despite experiencing such side effects as nausea, vomiting, dizziness, dry mouth, palpitation, hypersomnolence, and euphoria. Therefore,based on the results, cannabis can increase the
qualityof life, decrease pain and should be regarded as an alternative medication for specific patients.
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