Efficacy and Safety of Ya Khiao-Hom Powder for the Treatment of Aphthous Ulcer
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Abstract
Ya Khiao-Hom Powder (KHP) is a Thai traditional medicine preparation in the National List of Essential
Medicines. The remedy has been used to relieve fever as well as the symptoms of aphthous ulcer. This quasiexperimental study aimed to evaluate the safety and efficacy of KHP for the treatment of aphthous ulcer and was conducted in 100 patients of Namphong Hospital. The subjects were equally divided into two groups. The experimental group received KHP 1 gram dissolved in 15 ml of warm water to be taken orally twice daily before meal in the morning and evening as well as the application of KHP over the ulcers 4 times daily after meal and at bedtime, while the subjects in the control group received 0.1% triamcinolone oral paste, apply as thin film cover the ulcers 3-4 times daily after meal and at bedtime. The sizes of the ulcers and pain scores were measured and recorded on days 0, 2 and 6. Overall satisfaction of the treatment and side effects were also recorded. The results showed that the mean ages of the experimental group and the control group were 53.1 years and 55.2 years, respectively. The number of oral ulcers in each subject in both groups was 1–3. On day 0, the mean ulcer size at the 1st position in the experimental group was significantly greater than that in the control group (p < 0.05), but those in the 2nd and 3rd positions were not significantly different (p ≥ 0.05), while on day 2, the mean ulcer size at all positions in the experimental group greatly reduced but was not significantly different from that in the control group (p ≥ 0.05). On day 6, all oral ulcers healed in all patients in the experimental group, while the healing rate in the control group was 74.0%. On days 2 and 6, the mean pain score in the experimental group was significantly lower than that in the control group (p < 0.05). In addition, no adverse effects were found. In conclusion, this study has shown that
KHP is effective for the treatment of aphthous ulcer without causing any side effect
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