Development of Sukkasemnoi Traditional Medicine in Tablet Dosage Form
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Abstract
Sukkasemnoi recipe is a Thai traditional medicine indicated for insomnia. The objective of this study was to
develop Sukkasemnoi recipe in tablet dosage form. The study was divided into three parts: (1) preformulation study: micromeritic studies including microscopic study, sieve analysis and flow property study; (2) tablet preparation using wet granulation method; and (3) tablet evaluation. Results and discussion: (1) Microscopic study revealed irregular particle shapes and wide particle size distribution of crude drug powder. Sieve analysis showed a bimodal distribution with an average particle size of 622.41 microns. Angle of repose was 38.99 ± 0.94 degrees; and its bulk density, tapped density and compressibility index were 0.41 g/ml, 0.67 g/ml and 38.33%, respectively, indicating poor flow property. (2) Tablet preparation: The tablets were prepared by wet granulation. Each 500-mg tablet contained 250-350 mg of the active ingredient. (3) Tablet evaluation: Physical appearance of the prepared tablets was brownish green in color with a mild characteristic odor and bland taste. Selected formulations had acceptable physical properties (weight variation, friability, disintegration time) according to the United States Pharmacopeia, Volume 42. Drug release at 30 minutes (T30) was greater than 80%. Accelerated stability testing revealed that heat and humidity had a significant effect on physical properties of the tablets.
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