Herbal Capsule Preparation from Water Extract of Chantaleela Recipe

Abstract

This study aimed to prepare an aqueous extract of Chantaleela herbal recipe, a traditional anti-fever decoction, and to develop a capsule formulation. The aqueous extract of Chantaleela recipe was prepared using the spray drying technique. The properties of extract powder were evaluated and the quality control tests for capsules were performed. The results showed that the proportion of water soluble extractive of Chantaleela recipe was 14.23 ± 0.26% w/w. After optimizing the spray-drying parameters, the optimal conditions were as follows: inlet temperature at 110 ºC and volume flow of 27.22 m³/h with the feed flow of 2.10 ml/min. The obtained highest yield was 10.87 ± 0.49% w/w. For the property study, the spray-dried powder showed an angle of repose in the range of 32.08–35.80 degrees. Its bulk and tapped density were 394.50 ± 0.12 and 625.00 ± 0.00 mg/ml, respectively, and its moisture content was 3.73 ± 0.20% w/w. The extract was developed as 250-mg capsules, each containing 108.71 mg of dried extract and 154.50 mg of corn starch. The angle of repose of the formulation was 31.39–32.41 degrees. The bulk and tapped density were 400.10 ± 0.00 and 639.10 ± 0.06 mg/ml, respectively, with the moisture content of 4.15 ± 0.36% w/w. For the quality control of the Chantaleela capsules, it was found that there was no damage to the external characteristics. Both the weight variation and disintegration time (<15.51 minutes) were in accordance with the USP 41-NF36 and the THP 2018.