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Ya-Mahanintangtong is a Thai herbal remedy listed in the National List of Essential Medicine 2018. According to Thai traditional medicine, this drug recipe possesses anti-infective effects and is used for the treatment of fever, pharyngitis and chickenpox. However, up till now there has been no scientific report regarding the efficacy and safety of Ya-Mahanintangtong remedy itself. Therefore, the objective of this study was to assess the anti-inflammatory effect of Ya-Mahanintangtong remedy. Thus, proinflammatory cytokines, tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) production were analyzed using ELISA. The result obtained indicated that the ethanolic extract exhibited higher inhibitory activity TNF-α than IL-6 with IC50 values of 33.09 ± 0.22 and 17.20 ± 0.65 µg/mL, respectively. This work demonstrated the anti-inflammatory effect of Ya-Mahanintangtong remedy in vitro which preliminarily support the use of this Thai folk medicine as an antipyretic and anti-inflammatory agent. However, additional evidence on its safety and efficacy is required. Both preclinical and clinical studies are necessary to ensure the use of this recipe clinically.
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2. Ogoina D. Fever, fever patterns and diseases called ‘fever’–a review. Journal of Infection and Public Health. 2011;4(3):108-24.
3. Dinarello CA. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. Journal of Endotoxin Research. 2004;10(4):201-22.
4. Mendez M, LaPointe MC. PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes. Hypertension. 2003;42(4):844-50.
5. Food and Drug Administration. Announcement of the National Drug System Development Committee on National Essential Drug List 2018 [Internet]. 2018 January 19 [cited 2019 May 30]; Food and Drug Administration: Available from: https://www.fda.moph.go.th/sites/drug/Shared%20Documents/New/nlem2561.PDF
6. Thai Traditional Medicine Development Foundation. Thai Traditional Pharmacy book. 1st edition. Bangkok: Phikanes Printing Center; 2005.
7. Prasitpuriprecha C, Damkliang A, Surintha P, Deelum W. Immunomodulating, antioxidant and antimicrobial activities of northeastern Thai edible plant and medicinal plant extracts. Isan Journal of Pharmaceutical Sciences. 2009;5(2):99-107.
8. Mahesh SK, Jayakumaran NA. Antibacterial, cytotoxic and antioxidant potential of different extracts from leaf, bark and wood of Tectona grandis. International Journal of Pharmaceutical Sciences and Drug Research. 2010;2(2):155-8.
9. Shafiei Z, Shuhairi NN, Md Fazly Shah Yap N, Sibungkil HCA, Latip J. Antibacterial activity of Myristica fragrans against oral pathogens. Evidence-Based Complementary and Alternative Medicine. 2012;1-7.
10. Chakrapani P, Venkatesh K, Singh BCS, Jyothi BA, Kumar P, Amareshwari P, Rani AR. Phytochemical, pharmacological importance of Patchouli (Pogostemon cablin(Blanco) Benth) an aromatic medicinal plant. International Journal of Pharmaceutical Sciences Review and Research. 2013;21(2):7–15.
11. Cao GY, Xu W, Yang XW, Gonzalez FJ, Li F. New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production. Food Chemistry. 2015;173:231–7.
12. Cuong TD, Hung TM, Na M, Ha DT, Kim JC, Lee D, Ryoo SW, Lee JH, Choi JS, Min BS. Inhibitory effect on NO production of phenolic compounds from Myristica fragrans. Bioorganic & Medicinal Chemistry Letter. 2011;21(22):6884–7.
13. Li YC, Liang HC, Chen HM, Tan LR, Yi YY, Qin Z, Zhang WM, Wu DW, Li CW, Lin RF, Su ZR, Lai XP. Anti-Candida albicans activity and pharmacokinetics of pogostone isolated from Pogostemonis Herba. Phytomedicine. 2012;20(1):77-83.
14. Park SY, Neupane GP, Lee SO, Lee JS, Kim MY, Kim SY, Park BC, Park YJ, Kim JA. Protective effects of Pogostemon cablin Bentham water extract on inflammatory cytokine expression in TNBS-induced colitis in rats. Archives of Pharmacal Research. 2014;37(2):253-62.
15. Dégbé M, Debierre-Grockiego F, Tété-Bénissan A, Débare H, Aklikokou K, Dimier-Poisson I, Gbeassor M. Extracts of Tectona grandis and Vernonia amygdalina have anti-Toxoplasma and pro-inflammatory properties in vitro. Parasite. 2018;25:1-8.
16. Reanmongkol W, Subhadhirasakul S, Bouking P. Antinociceptive and antipyretic activities of extracts and fractions from Dracaena loureiri in experimental animals. Songklanakarin Journal of Science and Technology (SJST). 2003;25(4):467-76.