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Currently, incidence of new diabetic patients in Thailand increased. Diabetes is a non-communicable disease that cause of premature death. For this reason, The Ministry of Public Health realize of prevention and focusing on screening in the risk groups and recommendation in changing lifestyle. Unfortunately, the attempts are not success. With this reason French maritime pine bark extract may be an alternative in slow down the occurrence of diabetes in the future. The substance from French maritime pine bark extract. which is extracted from the fresh bark of the French maritime pine trees. The French maritime pine bark extract is a Phytochemical Flavonoids groups. The main mechanism of French maritime pine bark extract is grasping the enzyme of alpha glucosidase. This results in the decreasing conversion from carbohydrates to glucose and subsequently lowering blood sugar level. The objectives were study on effectiveness of French maritime pine bark extract on lowering fasting plasma glucose, waist circumference, bodyweight, BMI and HbA1C in prediabetes patients. The study was double-blind randomized placebo-controlled experimental trial. The thirty-two volunteers between aged 35 to 60 years old were randomized into two groups. The test group of sixteen volunteers received 50 mg of French maritime pine bark extract orally 2 capsules per day for a period of 12 weeks compared with control group received placebo. The parameters such as fasting plasma glucose, waist circumference, bodyweight, BMI and HbA1C were measured before and after the experiment. After 12 weeks; fasting plasma glucose, waist circumference, bodyweight and BMI in the test group were decreased with statistical significance at 95% confidence level while HbA1C in the test group was tended to decrease more than the control group but not statistically significant. In addition, side effects were not found.
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