Efficacy of an Add-on Treatment in Type 2 Diabetes Mellitus with Momordica charantia (Bitter Melon) Capsules

Main Article Content

จตุพร พลอยล้วน

Abstract

Introduction: Many studies showed that bitter melon could be used as antidiabetic drug in type 2 diabetes mellitus. Objective: This study aim to evaluate antidiabetic effect to hemoglobin A1C, fasting blood sugar, safety and side effect of bitter melon in type 2 diabetes mellitus patients Methodology: Non-randomized controlled quasi-experimental study, 33 diabetic patients were recruited. Continued current antidiabetic medication for 4 weeks, then add-on treatment by bitter melon 2,700 mg/day. Follow up every 4 week. Blood test for HbA1C, fasting blood sugar, eGFR and liver enzyme. Result: HbA1C was reduced at average 0.42 (p < 0.001), no significant change in fasting blood sugar, kidney function and liver function. Side effect of bitter melon was found that there were dyspepsia patients 6% at 4th and 8th weeks and clinical hypoglycemic patients 6% at 8th and 12th weeks. Conclusion: This primary treatment study shows that Bitter Melon capsules as an Add-on Treatment can reduce HbA1C in type 2 diabetes mellitus on 33 patients. No serious adverse effects found in strictly to protocol patients. Further clinical studies should be conducted on larger populations to confirm and in order to apply the results of the study to the therapy of type 2 diabetes patients.

Downloads

Download data is not yet available.

Article Details

Section
Original Articles

References

1. Diabetes Association of Thailand. Clinical practice guideline for diabetes 2017. 3rd ed. Pathum Thani: Romyen media company limited; 2017. 211 p. (in Thai)
2. Department of Disease Control, Ministry of Public Health. Diabetes campaigns 2017. Nonthaburi: Department of Disease Control; 2017. 3 p. (in Thai)
3. Division of Non Communicable Disease, Ministry of Public Health. World diabetes day 2017. [Internet]. 2017 [cited 2018 Jun 6]; Available from: www.thaincd.com (in Thai)
4. National Drug System Development Committee. National List of Essential Medicines B.E. 2556 (2013). Published in Government Gazette on 30 September B.E. 2556 (2013). (in Thai)
5. Ocvirk S, Kistler M, Khan S, Talukder S, Hauner H. Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh – an ethnobotanical survey. J Ethnobiol Ethnomed. 2013;9(1):43.
6. Ching SM, Zakaria ZA, Paimin F, Jalalian M. Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: a cross-sectional study in Malaysia. BMC Complement Altern Med. 2013 Jun 26;13:148.
7. Fernandes NPC, Lagishetty CV, Panda VS, Naik SR. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement Altern Med. 2007 Sep 24;7:29.
8. Phimarn W, Pulbutr P. Effects of Bitter melon (Momordica charantia) in the treatment diabetes mellitus: Mechanism of action and clinical effectiveness. Mahasarakham University. 2016.
9. Jia S, Shen M, Zhang F, Xie J. Recent advances in Momordica charantia: Functional components and biological activities. Int J Mol Sci. 2017 Dec;18(12):2555
10. Tripathi UN, Chandra D. The plant extracts of Momordica charantia and Trigonella foenum-graecum have anti-oxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus. Oxid Med Cell Longev. 2009;2(5):290–6.
11. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015 Jan 26;14:13.
12. Xie W, Zhao Y, Zhang Y. Traditional Chinese medicines in treatment of patients with type 2 diabetes mellitus. Evid Based Complement Alternat Med. 2011;2011:726723. 13. Krawinkel MB, Ludwig C, Swai ME, Yang R-Y, Chun KP, Habicht SD. Bitter gourd reduces elevated fasting plasma glucose levels in an intervention study among prediabetics in Tanzania. J Ethnopharmacol. 2018 Apr 24;216:1–7.
14. Nahas R, Moher M. Complementary and alternative medicine for the treatment of type 2 diabetes. Can Fam Physician. 2009 Jun;55(6):591–6.
15. Fuangchan A, Seubnukarn T, Jungpattanawadee D, Sonthisombat P, Ingkaninan K, Plianbangchang P, Haines ST. Retrospective study on the use of bitter melon for type 2 diabetes at Dansai Crown Prince Hospital, Thailand. Srinagarind Medical Journal. 2009;24(4):332–8.
16. Parildar H, Serter R, Yesilada E. Diabetes mellitus and phytotherapy in Turkey. J Pak Med Assoc. 2011 Nov;61(11):1116–20.
17. Yin RV, Lee NC, Hirpara H, Phung OJ. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: a systematic review and meta-analysis. Nutr Diabetes. 2014 Dec;4(12):e145.
18. Sotanaphun U, Trakoon-Osot W, Komindr S. Effect of Thai bitter gourd (Momordica charantia L.) on liver and renal function in type 2 diabetic patients. Nakhon Pathom: Faculty of Pharmacy, Silpakorn University; 2011.