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This research aims to study the preliminary effectiveness of Ya-Tha-Pra-Sen for pain reduction in Thai traditional diagnosis of Lom-Jub-Pong-Hang Kao. The subjects of this study were 50 volunteers with knee pain in Ban Lao Samakkee Health Promoting Hospital, Chiang Khwan District, Roi Et Province. This study divided into 2 groups 25 volunteers. Group 1 received Ya-Tha-Phra-Sen and group 2 received placebos by using a randomized double-blinded controlled trial. By allowing the volunteers to apply the treatments to their knees 3 times a day, morning, noon and before bedtime, for 7 days. Evaluated before and after the medication with volunteer data, visual analog scale (VAS) and western Ontario and McMaster University (WOMAC). An information questionnaire and volunteer data were analyzed by using descriptive statistics to estimate percent frequency, mean and standard deviation. VAS data and WOMAC data were analyzed by using paired sample t-test and independent sample t-test for comparison. This analysis finds most volunteers receiving Ya-Tha-Phra-Sen are female; 33 subjects, or 66.0 percent of subjects. They are mostly in the age range of 60 – 69 years; 14 subjects, or 28.0 percent of subjects Group 1, who received Ya-Tha-Phra-Sen after treatment, showed that knee pain decreased, knee joint stiffness decreased, ability to use the knee improved and the degree of knee movement improved significantly (p < 0.05). Group 2, who received placebos after treatment, showed that knee pain increased, knee joint stiffness increased, ability to use the knee reduced and the degree of knee movement reduced insignificantly (p > 0.05). Therefore, Ya-Tha-Phra-Sen in the Phra Narai recipe is effective in reducing knee pain, symptoms of stiffness, the ability to use the knee better and better movement of the knee. It should be used as an alternative to the treatment of Lom-Jub-Pong-Hang Kao in Thai traditional medicine or osteoarthritis of the knee.
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