The Preliminary Study of Yang Na (Dipterocarpus alatus Roxb. ex G.Don) Extracts on Anticancer and Antifungal Activities and the HPLC Analysis of the Phenolic Compounds

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Chawalit Yongram
Sarin Tadtong
Natthida Weerapreeyakul
Ploenthip Puthongking

Abstract

Dipterocarpus alatus Roxb. ex G.Don is a medicinal plant in Asia. In Thailand, this plant was used for skin, rheumatism and liver diseases. This study was determined to assess the anticancer and antifungal activities of the extracts from leaves, bark and twig of D. alatus as well as to identify the phenolic compounds in these extracts using HPLC analysis. The results suggest that all of extracts exhibited the highest cytotoxicity against Jurkat cancer cell line followed by HeLa and HepG2 cancer cell lines but do not show cytotoxicity against the non-cancerous cells (Vero cell line). Regarding its antifungal activity, extracts of the leaves and bark inhibited only T. mentagrophytes but have no capacity against other tested fungal stains. The HPLC analysis revealed the presence of, gallic acid in all extracts. Protocatechuic acid was found only in bark, while, p-coumaric acid and ferulic acid were found in twig. The result obtained suggested that D. alatus might be further explored for its contribution in cancer therapy. The obtained information could be useful for promoting the exploitation of the Thai medicinal plant.

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