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The aim of this study was to the effects of Lom Pa Kang formulations (LPKF) on heart rate variability. The 16 subjects were received poultice of LPKF for 20 min. Together with, the subjects were induced to stress with Mental arithmetic task for 5 min and were measured heart rate variability for 3 days. The results showed that LPKF significantly decreased Heart Rate values at day 2 and day 3 (p<0.001 and p<0.01 respectively) when compared to before receive poultice of LPKF. In addition, the LPKF significantly increased High Frequency values at all 3 days (p<0.05, p<0.05 and p<0.001 respectively) when compared to before receive poultice of LPKF. Moreover, the LPKF significantly decreased Low Frequency/ High Frequency values at All 3 days (p<0.01, p<0.05 and p<0.05 respectively) when compared to before receive poultice of LPKF. We conclude that LPKF has effect alterations of heart rate variability in stress patients by stimulating the function of parasympathetic pathways, a system that represents rest and digest.
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