Effects of using the Clinical Nursing Practice Guideline for Preventing of Complications from Peripheral Intravenous Administration of Increased Blood Pressure Agents
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Abstract
Abstract
This quasi-experimental study aimed to evaluate the effects of a nursing practice guideline for preventing complications from peripheral intravenous administration of vasopressor and inotropic agents. The study compared the incidence of complications between a control group and an experimental group receiving care based on the guideline, and also examined nurses’ satisfaction with its use. The sample consisted of patients receiving vasopressors (norepinephrine, epinephrine, and dopamine) and an inotrope (dobutamine) via peripheral intravenous lines in intensive and semi-critical care units at Nopparat Rajathanee Hospital. Participants were selected using purposive sampling, with 36 patients in each group. Data were collected using a complication record form for four medications, with a content validity index of 0.88. The intervention was a nursing practice guideline developed from a literature review. Data were analyzed using descriptive statistics and independent t-test.
The results showed no statistically significant differences in the incidence of phlebitis and extravasation between the two groups (t = 0.607, p = 0.263; t = 0.439, p = 0.330). However, the experimental group showed a lower incidence of complications, with phlebitis and extravasation rates of 8.30% and 13.90%, compared to 16.70% for both conditions in the control group. The severity of complications was also lower in the experimental group. No cases of grade 4 phlebitis were observed, and grade 4 extravasation occurred in only 2.80% of patients.
The findings indicate that the nursing practice guideline has the potential to reduce both the incidence and severity of complications, although it does not eliminate them completely. Nurses reported a high level of satisfaction with the guideline. The guideline may be applied in clinical practice to improve patient safety and the quality of nursing care.
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References
References
Pongpak Pittayaphan, Sirirat Chatchaisucha, Somkid Phochanaphan, et al. Survey of venous inflammation and related factors in Surgical patients receiving peripheral intravenous solutions. Journal of Intravenous and Chemotherapy Nursing Society of 2008;1(1):4-16. Thai.
Pajaree Sakwaleesakul. Factors associated with the incidence of venous thrombosis and the duration of Venous inflammation has occurred in a patient receiving injectable drugs that have an irritant effect on the veins. intensive care unit Internal Medicine. Documents supporting the meeting of Somdej Phra Phutthalertla Hospital Center Quality Development Somdej Phra Phutthalertla Hospital. 2018. Thai.
Simin D, Milutinovic D, Turkulov V, Brkic S. Incidence, severity and risk factor of peripheral intravenous cannula-induced complications: An observational prospective study. J Clin Nurs. 2019;28(9-10):1585-99.
Thitiporn Pathomjaruwat. The effect of nursing practice guidelines for the prevention and management of extravasation. Nursing Council Journal. 2016;31(2):81-95. Thai.
Thitiporn Pathomjaruwat. Guidelines for nursing patients receiving drugs or fluids that are at risk of Extravasation. Faculty of Nursing Thammasat University. 2020:1-11. Thai.
Johann DA, Danski MT, Vayego SA, Barbosa DA, Lind J. Risk factors for complications in peripheral intravenous catheters in adults: secondary analysis of a randomized controlled trial. Rev Lat Am Enfermagem. 2016;24:e2833.
Pajaree Sakwaleesakul, Usanee Siriwongprom. Effects of nursing practice guidelines for the prevention of atherosclerosis. Inflammation caused by taking norepinephrine. Christian University Journal. 2019;25(2):92-108. Thai.
Jutharat Yossuwan, Sumontha Chankham. Effect of the Nursing Program for Prevention of Peripheral Phlebitis in Patients Receiving Norepinephrine at Uttaradit Hospital. Academic Journal for Primary Health Care and Public Health System Development. 2024;2(2):132-43. Thai.
Kanjana Udomasataporn, Mayuree Prommarin. Effectiveness of Using Practice Guidelines for the Prevention of Phlebitis and Extravasation from the Use of Vasopressor Agents in the Cardiac Intensive Care Unit, Chiangrai Prachanukroh Hospital. Lanna Public Health Journal. 2018;14(1): 35-45. Thai.
Chortip Khochasanee. Effect of Aloe Vera Gel and Reparil Gel on the Incidence of Peripheral Phlebitis in Patients Receiving Peripheral Intravenous Nutrition. (Master's Thesis). Nakhon Pathom: Mahidol University; 2000. Thai.
Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of aloe vera clinical trials on prevention and healing of skin wound: a systematic review. Iran J Med Sci. 2019;44(1):1-9.
Yulu G, et al. Meta-analysis of Aloe vera for the prevention and treatment of chemotherapy-induced phlebitis. Int J Clin Med. 2016;9(6):9642-50.
Gao Y, Jiang T, Mei S, Zhang S, Zhu C, Sun Y. Meta-analysis of Aloe vera for the prevention and treatment of chemotherapy-induced phlebitis. Int J Clin Exp Med. 2016;9(6):9642-50.
Nopparat Rajathanee Hospital. Indicators of complications from peripheral intravenous fluid administration, fiscal years 2022-2024. Bangkok: Nopparat Rajathanee Hospital; 2024.Thai.
Kumpakam S, Chumjam B, Rungsri W, Janpetch N, Khiannukul N. The development of a nursing care system for patients receiving intravenous fluids at Nopparat Rajathanee Hospital. Journal of Nursing Division. 2022;49(2):37-52. Thai.
Villalba-Nicolau M, Chover-Sierra E, Saus-Ortega C, Ballestar-Tarin ML, Chover-Sierra P, Martinez-Sabater A. Usefulness of midline catheters versus peripheral venous catheters in an inpatient unit: a pilot randomized clinical trial. Nurs Rep. 2022;12(4):814-23.
Lamduan Meephap, et al. Testing the effectiveness of nursing practice guidelines for the management of peripheral intravenous
infiltration/extravasation in medical patients at Srinagarind Hospital. Khon Kaen University Hospital Journal. 2020;1(4):288-303. Thai.