The Effects of Modified Sequential Organ Failure Assessment Compared with Modified Early Warning Score in Sepsis Patients at Intensive Care Unit, Lerdsin Hospital
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Abstract
This quasi-experimental study aimed at comparing clinical outcome assessment of using the modified sequential organ failure assessment (MSOFA) and the modified early warning score (MEWS) in 338 severe sepsis patients. A sample of 166 patients was assigned to the control group and assessed with MEWS from 1st April-31th August 2019. A sample of 172 patients was assigned to the study group and assessed with MSOFA from 1st September 2019-31th January 2020. Clinical outcomes on mortality, complications, level of severity, and length of stay in ICU were collected and analyzed using Fisher's Exact test, Wilcoxon rank-sum test, Kaplan-Meier method and Log-rank test.
The findings revealed that there was significantly different (p<0.05) on death in ICU within 72 hours, complications, and length of stay in ICU of the patients between the study and the control groups. The average score on severity of organ failure among the deceased patients after ICU admission at the beginning 0, 24, 48, and 72 hours in the control group was increased (8.42, 11.67, 15.00, and 16.00 respectively). In contrast, the average score on severity of organ failure among the deceased patients in the control group was decreased (7.17, 5.88, 5.93, and 5.67 respectively). After 45 days of treatment, the patients had a 50% chance of survival. Comparing time period from admission to death of the patients, the study group was significantly different from the control group (p<.001). Thus, MSOFA was quite appropriate for assessing unexpected clinical outcomes of critically ill-patients. The severity of score changing in each parameter, in which increased, could indicate the degree of severity, failure, or malfunction of each organ system.
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References
Thailand. 2017; 21. Thai.
2. Galen LS van, Dijkstra CC, Ludikhuize J, Kramer MHH, Nanayakkara PWB. A Protocolised Once a Day Modified Early Warning Score (MEWS) Measurement Is an
Appropriate Screening Tool for Major Adverse Events in a General Hospital Population. PLOS ONE. 2016 Aug 5;11(8):e0160811.
3. Fujishima S. Organ dysfunction as a new standard for defining sepsis. Inflamm Regen [Internet]. 2016 Nov 15 [cited 2019 Sep 22];36. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725936/
4. Guirgis FW, Brakenridge S, Sutchu S, Khadpe JD, Robinson T, Westenbarger R, et al. The long-term burden of severe sepsis and septic shock: Sepsis recidivism
and organ dysfunction. J Trauma Acute Care Surg. 2016;81(3):525–32.
5. Baradari A G, Sharifi H, Firouzian A, Daneshiyan M, Aarabi M, Talebiyan Kiakolaye Y, et al. Comparison of Proposed Modified and Original Sequential Organ
Failure Assessment Scores in Predicting ICU Mortality: A Prospective, Observational, Follow-Up Study. Scientifica. 2016;2016:1–5.
6. Grissom CK, Brown SM, Kuttler KG, Boltax JP, Jones J, Jephson AR, et al. A Modified Sequential Organ Failure Assessment (MSOFA) Score for Critical Care Triage.
Disaster Med Public Health Prep Internet]. 2010 Dec [cited 2018 Sep 1];4(4). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811929/
7. Tiam Suwan, Mala Homor, Yindee Sukth, Mahout P, Prasert Sri. The Development Caring System of Critical Sepsis Patients by Case Management at
Sunprasithtiprasong Hospital, Ubon Ratchathani. Journal of Nursing and Health Care. 2017;35(1):184–93.
8. Sendagire C, Lipnick MS, Kizito S, Kruisselbrink R, Obua D, Ejoku J, et al. Feasibility of the modified sequential organ function assessment score in a resource-
constrained setting: a prospective observational study. BMC Anesthesiol [Internet]. 2017 Jan 26 [cited 2019 May 5];17. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267406/
9. Ebrahimian A, Ghasemian-Nik H, Ghorbani R, Fakhr-Movahedi A. Development a Reverse Triage System Based on Modified Sequential Organ Failure
Assessment for Increasing the Critical Care Surge Capacity. Indian J Crit Care Med. 2018;22(8):575–9.
10. Zhang Y, Khalid S, Jiang L. Diagnostic and predictive performance of biomarkers in patients with sepsis in an intensive care unit. J Int Med Res. 2019;47(1):44–
58.
11. Raith EP, Udy AA, Bailey M, McGloughlin S, MacIsaac C, Bellomo R, et al. Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital
Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit. JAMA. 2017;317(3):290–300.
12. Li W, Wang M, Zhu B, Zhu Y, Xi X. Prediction of median survival time in sepsis patients by the SOFA score combined with different predictors. Burns Trauma.
2020;(8 tkz006):1-10.
13. Impact of infections on the survival of hospitalized advanced cancer patients. - PubMed - NCBI [Internet]. [cited 2020 May 16]. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/22071166
14. Degoricija V, Sharma M, Legac A, Gradiser M, Sefer S, Vucicević Z. Survival analysis of 314 episodes of sepsis in medical intensive care unit in university hospital:
impact of intensive care unit performance and antimicrobial therapy. Croat Med J. 2006;47(3):385–97.