Insights into the Kidney Tissue Proteins Signaling Responded to Sodium Intake Using Multiplex Quantitative Proteomics
Keywords:Kidney tissue proteome, Sodium intake
Dietary sodium intake has been linked to the amount of kidney proteins in the body. High sodium intake can lead to an increase in the amount of proteins found in the kidneys, which can in turn lead to an increased risk of hypertension and other kidney-related health issues. In this study, the difference levels of sodium rat chow were used to alter rats' kidney tissue. Body weight was not affected by sodium intake. Urine volume was increased in high sodium group, and urine osmolality was decreased in low sodium intake compared to control. The homogenized kidney tissues were analyzed by multiplex quantitative proteomics. Quantitative analysis showed that total proteins data revealed 4054 proteins in kidney tissue at p<0.05. Among this, low sodium diet showed 259 significantly difference proteins compared to control. High sodium diet showed 357 significantly difference proteins compared to control. Protein-proteins interaction analysis showed the predominant signaling pathway are serine/threonine metabolism and proteins trafficking.
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