Anti-hyperlipidemic Property of Cinnamon Stomachic Mixture: A Pilot Study
Keywords:anti-hyperlipidemic property, Cinnamon stomachic mixture, hepatoprotective effect
Introduction: Cinnamon stomachic mixture, one of the Thai traditional herbal recipes, is in the National herbal drug lists in Thailand. It has long been prescribed for treating flatulence and dyspepsia. As already known, cinnamon demonstrated the potential for reducing blood lipid and glucose. In this pilot study, we investigated the anti-hyperlipidemic property of cinnamon stomachic mixture.
Materials and methods: The open-label, one single arm, prospective, pilot study was conducted at Ampur Muang District Primary Care Center, Prapokkloa Branch, Chanthaburi province, Ministry of Public Health, Thailand. Cinnamon stomachic mixture was produced from the GMP certified pharmaceutical company (Thongtong Osoth). The quality control was performed at Faculty of Pharmacy, Mahidol University. Subjects were recruited with specific inclusion and exclusion criteria. Blood chemistry including complete blood count were investigated for evaluation of the safety. All subjects were advised to take 2 tablespoons of the mixture after mealtime, 3 times daily for total 2 months. At the end of the first and second months, all subjects were asked to follow up with physical examination, blood chemistry tests, the same as done at the beginning. The anti-hyperlipidemic effects of the cinnamon stomachic mixture were assessed as the primary outcome.
Results: Based on our results, the decreasing of total blood cholesterol and triglyceride, before and after herbal recipe ingestion, was detected, but no statistical difference was observed. Other blood chemistry and complete blood count were not statistically changed. Interestingly, the statistical difference with p value = 0.034 was found in AST level, at 2 months.
Conclusion: Cinnamon stomachic mixture could reduce total cholesterol and triglyceride level, but not significant. The potent hepatoprotective property of cinnamon stomachic mixture is shown in this investigation. However, more clinical studies are still needed to be assure of the lipid lowering property of cinnamon stomachic mixture in patients with dyslipidemia.
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