Stonebreaker activity review of seed-under-leaf, Phyllanthus niruri



Herb, Phyllanthus niruri, Plant, Seed-under-leaf, Stonebreaker


Phyllanthus niruri (Family: Phyllanthaceae) known as a seed-under-leaf, is one of the traditional medicinal plants. It is widely used in anti-nephrolithiasis and anti-urolithiasis or stone removal treatment since it is able to modify the structure, shape, and texture of the stone to a smoother and probably more fragile form, which could contribute to the elimination and dissolution of stone. Further, it has been shown to possess anticancer, antidiabetic, anti-hepatotoxic, anti-hypertensive, anti-inflammatory, antimicrobial, and antioxidant properties. Its phytochemical substances are alkaloids, coumarins, flavonoids, saponins, tannins, and terpenoids. The other important constituents are astragalin, geranin, hypophyllanthin, nirtetralin, phyllanthenol, phyllanthin, phyllochrysine, phyltetralin, and quercetin, and all of these contribute to its remedial properties. This is a brief overview of the stonebreaker activity of P. niruri to further provide an up-to-date review showing its importance.

Keywords: Herb, Phyllanthus niruri, Plant, Seed-under-leaf, Stonebreaker


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How to Cite

Jiraungkoorskul W. Stonebreaker activity review of seed-under-leaf, Phyllanthus niruri. J. Med. Glob. [Internet]. 2022 May 21 [cited 2024 Feb. 27];1(1):59-65. Available from: