Chromosomal abnormalities associated with local recurrence or pulmonary metastasis of giant cell tumor of bone in Thai adults: a prospective cohort study with 6 years of follow-up

Authors

  • Pakpoom Ruangsomboon Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Worapa Heepchantree Research Department, Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand
  • Pissanu Reingrittha Department of Orthopaedic Surgery, Faculty of Medicine, Buddhachinaraj Hospital, Thailand
  • Rapin Phimolsarnti Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand https://orcid.org/0000-0002-6045-3496
  • Saranatra Waikakul Faculty of Medicine, BangkokThonburi University, Thailand https://orcid.org/0000-0001-8474-336X

Keywords:

Chromosomal abnormalities, pulmonary metastasis, giant cell tumor of bone, Thai adults, local recurrence, gene

Abstract

Background: Giant cell tumor (GCT) of bone demonstrates chromosomal abnormalities. This study aimed to investigate the prognostic role of chromosomal abnormalities of primary GCT of bone relative to local recurrence or pulmonary metastasis.
Methods: This prospective longitudinal cohort study with 6 years of follow-up included consecutive patients with primary GCT of bone that were surgically treated during 2011 to 2013 at the Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. All patients underwent surgical resection with extended intralesional curettage and phenol local adjuvant therapy. Systematic cytogenetic analysis compared cytogenetic abnormalities between patients with and without local recurrence or pulmonary metastasis. Fifteen patients were eligible, enrolled, and had successful cytogenetic analysis.
Results: The median follow-up time was 46 months (interquartile range [IQR]: 32-58). Five patients experienced local recurrence or pulmonary metastasis with a median time to recurrence of 6 months (IQR: 3.25-10.5). The mean number of abnormal cells in the primary culture compared between those with local recurrence or pulmonary metastasis and those without was 24.4 vs. 9.6 cells, respectively (p=0.04). A similar pattern was observed in the cultures of the subsequent four passages (all p<0.05). Forty-five patterns of clonal telomeric association (tas) were observed in passaged cultures. Six tas patterns were associated with local recurrence or pulmonary metastasis, including tas(11;19)(p15;q13.4), tas(15;19)(q26.3;q13.4), tas(15;22)(p13;p13), tas(16;19)(p13.3;q13.4), tas(17;19)(p13;q13.4), and tas(19;22)(q13.4;q13).
Conclusions: The mean number of abnormal cells and the six identified TAS patterns may be valuable prognostic factors for local recurrence or pulmonary metastasis of GCT tumor of bone.

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Author Biography

Saranatra Waikakul, Faculty of Medicine, BangkokThonburi University, Thailand

Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

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Published

2022-05-22 — Updated on 2022-05-21

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Ruangsomboon P, Heepchantree W, Reingrittha P, Phimolsarnti R, Waikakul S. Chromosomal abnormalities associated with local recurrence or pulmonary metastasis of giant cell tumor of bone in Thai adults: a prospective cohort study with 6 years of follow-up. J. Med. Glob. [Internet]. 2022 May 21 [cited 2023 Jan. 29];1(1). Available from: https://he01.tci-thaijo.org/index.php/JMedGlob/article/view/255952

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