The correlation of levels carcinoembryonic antigen (CEA) in the blood against colorectal cancer.
Keywords:
Carcinoembryonic antigen (CEA), Colorectal cancer, Colorectal cancer screeningAbstract
There are several methods of screening for colorectal cancer, including stool testing. Blood test for levels of cancer markers and visual inspection. Each method has different limitations, sensitivity and specificity. Aim: The aim to determine the efficacy of colorectal cancer screening by CEA and stool markers comparison with colonoscopy and the correlation between CEA levels in the blood and the detection of markers in the stool with colorectal cancer of patients in Chao Phraya Yommarat Hospital. Methods: In this study a retrospective study of 289 people who underwent colonoscopy. A fecal sample was obtained on the day before colonoscopy and all subjects underwent diagnostic colonoscopy with biopsy confirmation. Results: The sensitivity of the four stool markers (hHb, hTf, hCp, hLf) and the serum CEA were 97.6%, 95.1%, 97.6%, 80.5% and 87.8% respectively. The specificity was 70.2%, 60.0%, 36.7%. 87.1 and 45.6, respectively. The study also found that subjects who tested positive for hHb or hLf or CEA > 5.0 ng/ml were more likely to detect colorectal cancer than those who were negative (aOR = 23.7, P = 0.004, aOR = 12.9, P < 0.001 and aOR = 8.9, P = 0.003, respectively). In summary, the CEA level in the blood greater than 5.0 ng/ml, the detection of markers, hHb and hLf in the feces. It is associated with colorectal cancer.
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