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Introduction Chronic Obstructive Pulmonary Disease or COPD has been reported as the third
leading cause of death in the world. However, the cause of this disease is still unclear. Several
reports reveal that COPD is associated with free radicals derived from smoking, pollution and
biochemical reactions in the body. It induces chronic inflammation of bronchus and emphysema
including mucus hypersecretion exudate. Nowadays, COPD cannot be cured. However, many
studies report that antioxidants can prevent and reduce the free radicals that are the major
cause of this disease.
Objective To review the etiology and pathogenesis of COPD as well as its relationship to
antioxidants for the prevention and treatment of this disease
Conclusion Antioxidant is one of choices that can inhibit free radicals in COPD. However, COPD
cannot be cured because the insufficient levels of antioxidants. Moreover, development of
disease induced with free radicals for long time activates chronic inflammation and damage
the respiratory system. Therefore, the mechanism of this disease is still be explored for the
effective treatment in COPD patients.
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