Lead Exposure and Health Effects in Pregnant Women and Children

Main Article Content

Donrawee Waeyeng
Supabhorn Yimthiang

Abstract

            Lead is a heavy metal that contaminates the environment and everyday products. Lead has a serious impact on human health. Lead can enter the body through breathing, ingestion, absorption through the skin, and absorption through the placenta. Pre- and post-natal lead exposure in the mother presents a high risk to both the mother and the child. It will put the mother at risk of anemia, gestational hypertension, spontaneous abortion and also has a serious impact on a child's brain function and body growth. Numerous studies have shown the effects of lead on children’s health such as intellectual disability, delayed development, Attention Deficit Hyperactivity Disorder, etc. The measurement of pre-natal lead levels from the umbilical cord of a child found that the blood lead levels ranged from 0.44 to 4.60 µg/dL, demonstrating a correlation with limited cognitive function, especially in boys aged 36 months. Moreover, children with blood lead levels below 10 µg/dL will have low Intelligence Quotient (IQ), learning problems, short stature, developmental delays, a lack of concentration and may have problems with social behavior when entering adulthood. According to research studies in Asia and Africa, lead exposure during pregnancy has severe effects on the mother and fetus. In Thailand, the data on the impact of blood lead levels of pregnant women is not available. However, there is evidence of lead contamination in the environment, occupational exposure to lead (both in the workers themselves and in their children), and exposure through living close to certain industrial sites.


             Studying the status of lead exposure in pregnant women, launching guidelines for the monitoring of lead exposure, and screening for lead exposure in pregnant women from the first trimester is very important to minimize the effects. Relevant agencies should establish guidelines for the screening of lead exposure in all pregnant women in Thailand. Alongside this, there should be the implementation of environmental lead assessment in the community, to prevent negative effects on the health of pregnant women, and severe effects on infants’ brains and nervous systems, including the occurrence of chronic diseases in the future.

Article Details

Section
Academic Article

References

Yimthiang S, Waeyang D, Kuraeiad S. Screening for elevated blood lead levels and related risk factors among Thai children residing in a fishing community. Toxics 2019;7(4):54.

Silver MK, Li X, Liu Y, Li M, Mai X, Kaciroti N, et al. Low-level prenatal lead exposure and infant sensory function. Environ Health 2016;15(1):65.

Sindhu KN, Bondu JD, Ganesan SK, Syed C, Kang G, Mohan VR. Blood lead levels in mother-infant Pairs. Indian J Pediatr 2018;85(12):1143-4.

Yao H-y, Huang X-h. The blood lead level and pregnant outcome in pregnant women with non-occupational lead exposure. Zhonghua Fu Chan Ke Za Zhi 2003;38(6):340-2.

Vigeh M, Saito H, Sawada S-I. Lead exposure in female workers who are pregnant or of childbearing age. Industrial health 2010;49(2):255-61.

Disha, Sharma S, Goyal M, Kumar PK, Ghosh R, Sharma P. Association of raised blood lead levels in pregnant women with preeclampsia: a study at tertiary centre. Taiwan J Obstet Gynecol 2019;58(1):60-3.

Hamadneh J, Hamadneh S, Massadeh A, Kassab M, Al-Bayyari N, Khader Y, et al. Blood lead level and correlation with pregnancy-associated anemia. AMJ 2018;11(4):219-26.

Hassanian-Moghaddam H, Zamani N, Hamidi F, Farnaghi F, Gachkar L. Blood lead levels in pregnant women referring to midwifery clinic in a referral center in Tehran. J Res Med Sci 2018;23:88.

Rimbaud D, Restrepo M, Louison A, Boukhari R, Ardillon V, Carles G, et al. Blood lead levels and risk factors for lead exposure among pregnant women in western French Guiana: the role of manioc consumption. J Toxicol Environ Health A 2017;80(6):382-93.

Taylor CM, Golding J, Emond AM. Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study: a prospective birth cohort study. BJOG 2015;122(3):322-8.

Taylor CM, Golding J, Hibbeln J, Emond AM. Environmental factors predicting blood lead levels in pregnant women in the UK: the ALSPAC study. PLoS One 2013;8(9):e72371-e.

La-Llave-León O, Estrada-Martínez S, Manuel Salas-Pacheco J, Peña-Elósegui R, Duarte-Sustaita J, Candelas Rangel JL, et al. Blood lead levels and risk factors in pregnant women from Durango, Mexico. Arch Environ Occup Health 2011;66(2):107-13.

Silbergeld EK. Lead in bone: implications for toxicology during pregnancy and lactation. Environ Health Perspect 1991;91:63-70.

Kumar A, Kaur S. Calcium: a nutrient in pregnancy. J Obstet Gynaecol India 2017;67(5):313-8.

Hu H, Tellez-Rojo MM, Lamadrid-Figueroa H, Hernández-Avila M, Bellinger D, Mercado-García A, et al. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Environ Health Perspect 2006;114(11):1730-5.

Liu K-S, Hao J-H, Shi J, Dai C-F, Guo X-R. Blood lead levels during pregnancy and its influencing factors in Nanjing, China. Chinese Medical Sciences Journal 2013;28(2):95-101.

Hertz-Picciotto I, Schramm M, Watt-Morse M, Chantala K, Anderson J, Osterloh J. Patterns and determinants of blood lead during pregnancy. Am J Epidemiol 2000;152(9):829-37.

Namihira D, Saldivar L, Pustilnik N, Carreón GJ, Salinas ME. Lead in human blood and milk from nursing women living near a smelter in Mexico City. J Toxicol Environ Health 1993;38(3):225-32.

Ettinger AS, Téllez-Rojo MM, Amarasiriwardena C, Bellinger D, Peterson K, Schwartz J, et al. Effect of breast milk lead on infant blood lead levels at 1 month of age. Environmental Health Perspectives 2004;112(14):1381-5.

Pongpunlert W. Lead poisoning. Chula Med J 1993;37(1):71-6. (in Thai).

Fioresi M, Simões MR, Furieri LB, Broseghini-Filho GB, Vescovi MVA, Stefanon I, et al. Chronic lead exposure increases blood pressure and myocardial contractility in rats. PLoS One 2014;9(5):e96900-e.

Fiorim J, Ribeiro Júnior RF, Silveira EA, Padilha AS, Vescovi MV, de Jesus HC, et al. Low-level lead exposure increases systolic arterial pressure and endothelium-derived vasodilator factors in rat aortas. PLoS One 2011;6(2):e17117.

Yazbeck C, Thiebaugeorges O, Moreau T, Goua V, Debotte G, Sahuquillo J, et al. Maternal blood lead levels and the risk of pregnancy-induced hypertension: the EDEN cohort study. Environ Health Perspect 2009;117(10):1526-30.

Borja-Aburto VH, Hertz-Picciotto I, Rojas Lopez M, Farias P, Rios C, Blanco J. Blood lead levels measured prospectively and risk of spontaneous abortion. Am J Epidemiol 1999;150(6):590-7.

Bellinger DC. Teratogen update: lead and pregnancy. Birth Defects Res A Clin Mol Teratol 2005;73(6):409-20.

Centers for Disease Control and Prevention. Premature birth. [Internet]. [cited 2020 December 21]. Available from: https://www.cdc.gov/reproductivehealth/features/premature-birth/index.html.

Vistica DT, Ahrens FA, Ellison WR. The effects of lead upon collagen synthesis and proline hydroxylation in the Swiss mouse 3T6 fibroblast. Archives of Biochemistry and Biophysics 1977;179(1):15-23.

Jelliffe-Pawlowski LL, Miles SQ, Courtney JG, Materna B, Charlton V. Effect of magnitude and timing of maternal pregnancy blood lead (Pb) levels on birth outcomes. Journal of Perinatology 2006;26(3):154-62.

Khunpradit S. Low birthweight: fetal origins of adult disease. Chula Med J 2003;48(5):309-22. (in Thai).

Potula V, Kaye W. Report from the CDC: is lead exposure a risk factor for bone loss? J Womens Health (Larchmt) 2005;14(6):461-4.

Zhu M, Fitzgerald EF, Gelberg KH, Lin S, Druschel CM. Maternal low-level lead exposure and fetal growth. Environ Health Perspect 2010;118(10):1471-5.

Zhang B, Xia W, Li Y, Bassig BA, Zhou A, Wang Y, et al. Prenatal exposure to lead in relation to risk of preterm low birth weight: a matched case-control study in China. Reprod Toxicol 2015;57:190-5.

Wiebe JP, Barr KJ. Effect of prenatal and neonatal exposure to lead on the affinity and number of estradiol receptors in the uterus. J Toxicol Environ Health 1988;24(4):451-60.

Rothenberg SJ, Schnaas L, Perroni E, Hernández RM, Martínez S, Hernández C. Pre- and postnatal lead effect on head circumference: a case for critical periods. Neurotoxicol Teratol 1999;21(1):1-11.

Schell LM, Denham M, Stark AD, Parsons PJ, Schulte EE. Growth of infants' length, weight, head and arm circumferences in relation to low levels of blood lead measured serially. Am J Hum Biol 2009;21(2):180-7.

Hong SB, Im MH, Kim JW, Park EJ, Shin MS, Kim BN, et al. Environmental lead exposure and attention deficit/hyperactivity disorder symptom domains in a community sample of South Korean school-age children. Environ Health Perspect 2015;123(3):271-6.

Chand DB, Rajarami GR. Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement. Interdiscip Toxicol 2015;8(4):159-68.

Jedrychowski W, Perera F, Jankowski J, Mrozek-Budzyn D, Mroz E, Flak E, et al. Gender specific differences in neurodevelopmental effects of prenatal exposure to very low-lead levels: the prospective cohort study in three-year olds. Early Hum Dev 2009;85(8):503-10.

Taylor CM, Kordas K, Golding J, Emond AM. Effects of low-level prenatal lead exposure on child IQ at 4 and 8 years in a UK birth cohort study. Neurotoxicology 2017;62:162-9.

Wang H-L, Chen X-T, Yang B, Ma F-L, Wang S, Tang M-L, et al. Case-control study of blood lead levels and attention deficit hyperactivity disorder in Chinese children. Environ Health Perspect 2008;116(10):1401-6.

Visanuyothin T, Pavasuthipaisit C, Wachiradilok P, Arunruang P, Buranasuksakul T. The prevalence of attention deficit/hyperactivity disorder in Thailand. Journal of Mental Health of Thailand 2013;21(2):66-75. (in Thai).

Afeiche M, Peterson KE, Sánchez BN, Schnaas L, Cantonwine D, Ettinger AS, et al. Windows of lead exposure sensitivity, attained height, and body mass index at 48 months. The Journal of Pediatrics 2012;160(6):1044-9.

Yang H, Huo X, Yekeen TA, Zheng Q, Zheng M, Xu X. Effects of lead and cadmium exposure from electronic waste on child physical growth. Environ Sci Pollut Res Int 2013;20(7):4441-7.

Burns JS, Williams PL, Lee MM, Revich B, Sergeyev O, Hauser R, et al. Peripubertal blood lead levels and growth among Russian boys. Environ Int 2017;106:53-9.

Bureau of Occupational and Environmental Diseases. Guideline for surveillance and prevent lead poisoning in children. [Internet]. [cited 2021 March 1]. Available from: http://envocc.ddc.moph.go.th/uploads/media/manual/T25620723.pdf. (in Thai).