Drug use evaluation (DUE) on appropriate use of Remdesivir in Covid-19 patients at Lam Plai Mat Hospital, Buriram Province

Abstract

Purposes : To study the factors associated with drug use evaluation of Remdesivir and compare the appropriateness of Remdesivir prescribing, clinical end-of-treatment outcomes and physician responses to pharmacist advice before and after use guideline of Remdesivir in treating Covid-19 patients.

Study design : Retrospective study.

Materials and Methods : Drug use evaluation of Remdesivir in treating all Covid-19 patients admitted to Lam Plai Mat Hospital, Buriram Province, between December 1, 2022 and June 30, 2024. Data were collected using a developed data collection form. Data were analyzed using descriptive statistics and chi-square values.

Main findings : Factors related to drug use evaluation of Remdesivir were the main diagnosis, patients on O₂, and the time from the onset of symptoms to receiving medication (p=0.001, p=0.041, and p<.001, respectively). When comparing drug use evaluation of Remdesivir after use guidelines found, the appropriateness of prescribing increased significantly (p<.001), increasing from 64.79 percent to 86.93 percent. Clinical outcomes and treatment completion did not affect the appropriateness of prescribing (p=0.266, p=0.503, respectively), and physicians' responses to pharmacists' advice resulted in an increased appropriateness of prescribing, with a statistically significant difference (p=0.025), increasing from 54.53 percent to 89.86 percent.

Conclusion and recommendations : Drug use evaluation of Remdesivir was found that having guidelines for prescribing drugs will help increase the appropriateness of prescribing drugs and reduce the problem of inappropriate prescribing. Increase confidence in patient care and doctors accept recommendations from pharmacists for safe results in patient care.