Outcomes and Factors Related to Antiretroviral Therapy in HIV/AIDS Patients Phonsai Hospital, Roi-Et Province

Abstract

Purposes : To study the results of treatment and factors related to the results of antiretroviral treatment in patients infected with HIV/AIDS in Phonsai Hospital, Roi-Et Province.

Study design : Retrospective descriptive study.

Materials and Methodes : The sample group consisted of 103 HIV/AIDS infected patients who met the inclusion criteria. Data were collected from patient medical records, the NAP plus program and pharmaceutical care records. Data were analyzed with using frequency, percentage, median, maximum, minimum, Fisher Exact Test and Spearman Rank Correlation Coefficient.

Main findings : The results of the study found that 51.50% of the sample were female. The median age was 52 years. 50.48% had marital status, 99.02% received the first drug regimen. The median duration of antiretroviral therapy was 17 years. The average CD4 count was 483.04 cells/mm³ and the level of viral load at the level < 50 copies/ml was 90.30%. The results of the correlation test found that gender, drug regimen, opportunistic infections or drug-resistant, duration of antiretroviral therapy and adherence were related to the results of antiretroviral treatment in terms of CD4 levels. Drug regimen, opportunistic infections or drug-resistant and adherence were related to the results of antiretroviral treatment in terms of viral load level at the statistical significance level of .05.

Conclusion and recommendations : In conclusion, the results of antiretroviral therapy were in accordance with the treatment guidelines. In terms of related factors; drug regimen, opportunistic infections or drug-resistant and adherence were related to the results of antiretroviral therapy in terms of both CD4 and viral load levels. Therefore, pharmacists and multidisciplinary teams should provide care according to guidelines and encourage patients to have greater adherence for good treatment results and preventing the opportunistic infection or drug-resistant to the patients in the future.