The Predictive Factors of Diabetic Nephropathy in Patient with Type 2 Diabetes Mellitus at Diabetes Mellitus Clinic, Takuapa Hospital, Phang Nga Province
Keywords:
Predictive factors, Diabetic nephropathy, Type 2 diabetes mellitusAbstract
Purposes : To study the predictive factors of diabetic nephropathy in patients with T2DM at Diabetes Mellitus Clinic, Takuapa Hospital, Phang Nga Province.
Study design : Case- control study
Materials and Methods : This study was case- control study, all data were collected from medical records and laboratory blood test of patients with T2DM at Diabetes Mellitus Clinic, Takuapa Hospital between January 1,2017 to December 31, 2020. The cases group was T2DM with diabetic nephropathy that eGFR < 60 mL/min/1.73 m2 with urine protein positive, while the control group had normal renal function. The statistical analyses were used descriptive statistics, Chi-square test, univariate analysis, multivariate analysis by multiple logistics regression. The statistical significant was set at p <.05
Main findings: The study group consisted of 150 patients, males 58.0%, mean age 54.94 years (SD=11.47), mean duration T2DM was 9.32 years (SD=5.06) The control group consisted of 300 patients, male 57.33%, mean age 57.84 years (SD=11.16), mean duration of T2DM was 10.24 years (SD=7.39). The statistical analysis revealed the predictive factors of diabetic nephropathy in patients with T2DM were body mass index > 30 (kg/m2) (Adjusted OR=3.74; 95%CI;1.16-5.61), duration T2DM > 20 year (Adjusted OR=3.66; 95%CI;2.25-6.52), Hypertension (Adjusted OR=2.06; 95%CI;1.33-6.91), FBS >140 mg/dL(Adjusted OR=2.12; 95%CI;1.85-3.89), and HbA1C > 8 mg% (Adjusted OR=2.86; 95%CI;1.29-6.26)
Conclusion and recommendation: The present study found out that the predictive factors of diabetic nephropathy in T2DM patients were body mass index >30 (kg/m2), more than 20 years diagnosis with T2DM, Hypertension, FBS >140 mg/dL, and HbA1C > 8 mg%.
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