针刺联合萘普生治疗膝骨关节炎患者的疗效研究：一项设有对照组的实验性研究
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摘要
本研究旨在探讨针刺联合非甾体抗炎药萘普生（naproxen）对膝骨关节炎患者疼痛、膝关节功能、生活质量及药物使用量的影响。本研究采用设有对照组的实验性研究设计。研究对象共 100 例，分为对照组 50 例和实验组 50 例。对照组接受萘普生 250 毫克治疗，实验组在接受萘普生治疗的基础上联合针刺治疗。针刺治疗每周 2 次，连续治疗4周。研究采用西安大略和麦克马斯特大学骨关节炎指数（Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC）、膝关节损伤与骨关节炎结局评分（Knee Injury and Osteoarthritis Outcome Score, KOOS）以及第 0 周至第 5 周的药物使用记录进行疗效评估。数据分析采用描述性统计、独立样本 t 检验、Mann–Whitney U 检验、卡方检验及 Fisher 精确检验，并以p<0.05 为差异具有统计学意义。研究结果显示，两组患者的基线资料大部分无显著差异，唯实验组年龄显著高于对照组（p<0.05）。治疗后，实验组 WOMAC 总分自第 1 周至第 4 周均较对照组显著降低。第 4 周时，实验组 WOMAC 总分均值为 33.8±29.9 分，对照组为 57.3±32.4 分，差异具有统计学意义（p<0.05）。此外，实验组在 KOOS 疼痛、日常生活活动能力以及运动和娱乐功能方面的评分，在多个时间点均显著高于对照组，尤其是在第 4 周差异更为明显（p<0.05）。同时，实验组每周萘普生用量均显著少于对照组（p<0.05）。第 5 周时，实验组药物使用量中位数为 1 片（四分位距 0.0–0.4），而对照组为 6 片（四分位距 2.0–8.0）。综上所述，针刺联合萘普生较单纯使用萘普生更有助于减轻膝骨关节炎患者的疼痛和疾病严重程度，改善膝关节功能，并减少非甾体抗炎药的使用量。然而，仍需进一步开展随机对照研究并进行长期随访，以验证其疗效及治疗效果的持续性。
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