Identifying the Chinese herbal medicine used in treating diabetic retinopathy: a data mining analysis
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Abstract
The objective of this study was to identify the frequency and association of Chinese medicine herbs in treating diabetic retinopathy (DR) in the past ten years. A search of the published literature was conducted by using keywords which were commonly associated with diabetic retinopathy, Chinese herbal medicine, Chinese medicine, traditional Chinese medicine and diabetic eye disease in the Chinese National Knowledge Infrastructure (CNKI), PubMed, ScienceDirect, and Springer Link databases. The papers which met inclusion criteria were entered into Microsoft Excel and IBM SPSS Modeler Subscription for a frequency analysis and association rule analysis. There were 25 papers that fit with the criteria. A total of 102 types of Chinese medicines were used in these 25 papers. It was found that the most frequently used Chinese medicine for DR were Dihuang (地黄), Huangqi (黄芪) and Danggui (当归). The top commonly associated Chinese medicine combinations were Huangqi (黄芪) and Dihuang (地黄); Dihuang (地黄) and Danggui (当归); Huangqi (黄芪) and Chuanxiong (川芎). The frequently used Chinese medicine mostly possessed the functions to activate blood, tonify Qi and nourish Yin, this indicated that DR basically had underlying pathological mechanism of "deficiency of Qi and Yin with blood stasis blocking the meridians and collaterals". Treatment principle of DR should consider focusing on tonify Qi and Yin, removing blood stasis, and nourishing the eyes.
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