Research progress on the mechanisms of polyphenols in the prevention and treatment of osteoporosis

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Published: Dec 30, 2023
Keywords:
polyphenols osteoporosis antioxidant bone formation bone resorption

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Xie Anna
Central Laboratory of Science and Technology Department, Longhua Hospital Shanghai University of Traditional Chinese Medicine, China
Zhangsun Zhengyuan
Central Laboratory of Science and Technology Department, Longhua Hospital Shanghai University of Traditional Chinese Medicine, China
Dai Weiwei
Central Laboratory of Science and Technology Department, Longhua Hospital Shanghai University of Traditional Chinese Medicine, China

Abstract

Osteoporosis is a common chronic skeletal disorder characterized by weakened bone fragility and increased risk of fractures, significantly impacting patients' quality of life. Finding effective preventive and therapeutic strategies is of paramount importance. Polyphenols, a group of naturally occurring active compounds widely present in plants, possess various physiological activities including antioxidant and anti-inflammatory properties. Multiple studies have shown that polyphenols can regulate bone metabolism through mechanisms such as antioxidation, anti-inflammation, promotion of bone formation, and inhibition of bone resorption. Moreover, polyphenols offer multiple benefits over traditional drugs, including their multitarget effects and natural non-toxic nature, making them a promising approach for the prevention and treatment of osteoporosis. This review summarizes the recent advances in understanding the mechanisms of polyphenols in preventing and treating osteoporosis, aiming to provide a theoretical basis and novel insights for the development of polyphenolic compounds as potential therapeutics for osteoporosis.

Article Details

Issue
Vol. 2 No. 2 (2023): July-December 2023
Section
Review Article

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