Rhizoma Zingiberis alleviate the neurotoxicity of Pinellia ternata

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วารสารการแพทย์แผนจีนในประเทศไทย ปีที่ 1 ฉบับที่ 1 มกราคม ถึง มิถุนายน 2565
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Published: Jun 30, 2022
Keywords:
Pinellia ternata zebrafish behavioral analysis neurotoxicity 6-gingerol

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Tan Lu
State Key Laboratory of Characteristic Chinese Medicine Resource of Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China; Chongqing Dadukou District Traditional Chinese Medicine Hospital, China
Kuang Qixuan
State Key Laboratory of Characteristic Chinese Medicine Resource of Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China
Guo Wenxiu
State Key Laboratory of Characteristic Chinese Medicine Resource of Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China
Li Xinai
State Key Laboratory of Characteristic Chinese Medicine Resource of Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China
Lei Lirong
State Key Laboratory of Characteristic Chinese Medicine Resource of Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China
Gong Leiqiang
State Key Laboratory of Characteristic Chinese Medicine Resource of Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China
Huang Lijun
School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, China
Guo Dale
State Key Laboratory of Characteristic Chinese Medicine Resource of Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China
Wang Dong
School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, China
Deng Yun
State Key Laboratory of Characteristic Chinese Medicine Resource of Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China

Abstract

Objective of this study was to evaluate the toxicity mitigation effect of Rhizoma Zingiberis on the neurotoxicity of Banxia (the tuber of Pinellia ternata). Methods: Using the zebrafish embryo stained with acridine orange and zebrafish behavioral evaluation system, the neurotoxicity of blank control group, Raw Banxia group (RB), Rhizoma Zingiberis processed Banxia group (RPB), and 6-gingerol processed Banxia (6-GPB) group were compared on the basis of the moving distance and speed as well as the degree and distribution of apoptotic cells. Results: The moving distance and average speed of zebrafish in the RB group were significantly higher than those in the blank control group (p<0.001), while the RPB groups and 6-GPB were lower than those of the RB group. Conclusion: Rhizoma Zingiberis can alleviate the neruotoxicity of Banxia and 6-gingerol can partly account for the alleviative effect.

Article Details

Issue
Vol. 1 No. 1 (2022): January-June 2022
Section
Original Article

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