Obstructive Sleep Apnea Prevalence, Upper Airway Dimensions, and Sleep Parameters in Skeletal Class III Malocclusion Patients Undergoing Orthognathic Surgery with Different Vertical Skeletal Patterns

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Thanakorn Kaewja
Nuntigar Sonsuwan
Kanich Tripuwabhrut

Abstract

Background: Craniofacial morphology’s relationship with airway dimensions has been extensively studied. Despite this, evidence regarding obstructive sleep apnea (OSA) prevalence and differences in airway dimensions among vertical skeletal patterns in skeletal Class III malocclusion patients undergoing orthognathic surgery is limited. Objective: To determine the prevalence of OSA and compare upper airway dimensions and sleep parameters among skeletal Class III patients with different vertical skeletal patterns. Materials and methods: The study involved 98 adult patients (39 male and 59 female) with skeletal Class III malocclusions undergoing orthognathic surgery. Patients were divided into three groups according to vertical skeletal patterns: high-angle (SN-GoGn > 33°; 47 patients), low-angle (SN-GoGn < 25°; 20 patients), and normal-angle (SN-GoGn 25-33°; 31 patients) groups. OSA prevalence and sleep parameters, including the apnea-hypopnea index and lowest oxygen saturation, were assessed using a portable level III polysomnography device. Cone beam computed tomography was performed, and upper airway dimensions, including nasopharyngeal, oropharyngeal, hypopharyngeal, and total upper airway volumes and minimum cross-sectional area, were measured using Dolphin Imaging software. Group differences were analyzed using ANOVA and post hoc Tukey tests (P < 0.05). Results: The prevalence of OSA among skeletal Class III malocclusion patients was 11 of 98 (11.22 %). Upper airway dimensions and sleep parameters did not differ significantly among vertical skeletal pattern groups. Conclusion: Despite a comparable OSA prevalence in skeletal Class III patients, screening for OSA is crucial in those with Class III malocclusion undergoing mandibular setback surgery, irrespective of vertical patterns.

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Kaewja T, Sonsuwan N, Tripuwabhrut K. Obstructive Sleep Apnea Prevalence, Upper Airway Dimensions, and Sleep Parameters in Skeletal Class III Malocclusion Patients Undergoing Orthognathic Surgery with Different Vertical Skeletal Patterns. Thai J Orthod [Internet]. 2024 Oct. 11 [cited 2024 Nov. 5];14(2):6-16. Available from: https://he01.tci-thaijo.org/index.php/THAIORTHO/article/view/268271
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References

Larson BE. Orthodontic preparation for orthognathic surgery. Oral Maxillofac Surg Clin North Am 2014;26(4):441-58.

Canellas JV, Barros HL, Medeiros PJ, Ritto FG. Sleepdisordered breathing following mandibular setback: a systematic review of the literature. Sleep Breath 2016;20(1):387-94.

He J, Wang Y, Hu H, Liao Q, Zhang W, Xiang X, et al. Impact on the upper airway space of different types of orthognathic surgery for the correction of skeletal Class III malocclusion: a systematic review and meta-analysis. Int J Surg 2017;38:31-40.

Hasebe D, Kobayashi T, Hasegawa M, Iwamoto T, Kato K, Izumi N, et al. Changes in oropharyngeal airway and respiratory function during sleep after orthognathic surgery in patients with mandibular prognathism. Int J Oral Maxillofac Surg 2011;40(6):584-92.

Yang HJ, Jung YE, Kwon IJ, Lee JY, Hwang SJ. Airway changes and prevalence of obstructive sleep apnoea after bimaxillary orthognathic surgery with large mandibular setback. Int J Oral Maxillofac Surg 2020;49(3):342-9.

Osman AM, Carter SG, Carberry JC, Eckert DJ. Obstructive sleep apnea: current perspectives. Nat Sci Sleep 2018;10:21-34.

Theprungsirikul W, Sutthiprapaporn P. Relationship between obstructive sleep apnea and extraction teeth in orthodontic treatment. Thai J Orthod 2024;14(1):41-67.

Schwab RJ, Gupta KB, Gefter WB, Metzger LJ, Hoffman EA, Pack AI. Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing. Significance of the lateral pharyngeal walls. Am J Respir Crit Care Med 1995;152(5 Pt 1):1673-89.

Dempsey JA, Skatrud JB, Jacques AJ, Ewanowski SJ, Woodson BT, Hanson PR, et al. Anatomic determinants of sleep-disordered breathing across the spectrum of clinical and nonclinical male subjects. Chest 2002;122(3):840-51.

Behrents RG, Shelgikar AV, Conley RS, Flores-Mir C, Hans M, Levine M, et al. Obstructive sleep apnea and orthodontics: an American association of orthodontists white paper. Am J Orthod Dentofacial Orthop 2019;156(1):13-28.

Senaratna CV, Perret JL, Lodge CJ, Lowe AJ, Campbell BE, Matheson MC, et al. Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 2017;34:70-81.

Neruntarat C, Chantapant S. Prevalence of sleep apnea in HRH Princess Maha Chakri Srinthorn Medical Center, Thailand. Sleep Breath 2011;15(4):641-8.

Kim SJ, Ahn HW, Hwang KJ, Kim SW. Respiratory and sleep characteristics based on frequency distribution of craniofacial skeletal patterns in Korean adult patients with obstructive sleep apnea. PLoS One 2020;15(7):e0236284.

Lowe AA, Fleetham JA, Adachi S, Ryan CF. Cephalometric and computed tomographic predictors of obstructive sleep apnea severity. Am J Orthod Dentofacial Orthop 1995;107(6):589-95.

Aboudara C, Nielsen I, Huang JC, Maki K, Miller AJ, Hatcher D. Comparison of airway space with conventional lateral headfilms and 3-dimensional reconstruction from conebeam computed tomography. Am J Orthod Dentofacial Orthop 2009;135(4):468-79.

Grauer D, Cevidanes LS, Styner MA, Ackerman JL, Proffit WR. Pharyngeal airway volume and shape from cone-beam computed tomography: relationship to facial morphology. Am J Orthod Dentofacial Orthop 2009;136(6):805-14.

El H, Palomo JM. Airway volume for different dentofacial skeletal patterns. Am J Orthod Dentofacial Orthop 2011;139(6):e511-21.

Alves M Jr, Franzotti ES, Baratieri C, Nunes LK, Nojima LI, Ruellas AC. Evaluation of pharyngeal airway space amongst different skeletal patterns. Int J Oral Maxillofac Surg 2012;41(7):814-9.

Zheng ZH, Yamaguchi T, Kurihara A, Li HF, Maki K. Threedimensional evaluation of upper airway in patients with different anteroposterior skeletal patterns. Orthod Craniofac Res 2014;17(1):38-48.

Celikoglu M, Bayram M, Sekerci AE, Buyuk SK, Toy E. Comparison of pharyngeal airway volume among different vertical skeletal patterns: a cone-beam computed tomography study. Angle Orthod 2014;84(5):782-7.

Dechkunakorn S, Chaiwat J, Sawaengkit P, Anuwongnukroh N, Taweesedt N. Thai adult norms in various lateral cephalometric analysis. J Dent Assoc Thai 1994;44:202-14.

Guijarro-Martínez R, Swennen GR. Three-dimensional cone beam computed tomography definition of the anatomical subregions of the upper airway: a validation study. Int J Oral Maxillofac Surg 2013;42(9):1140-9.

Lye KW. Effect of orthognathic surgery on the posterior airway space (PAS). Ann Acad Med Singap 2008;37(8):677-82.

Hatab NA, Konstantinović VS, Mudrak JK. Pharyngeal airway changes after mono- and bimaxillary surgery in skeletal Class III patients: cone-beam computed tomography evaluation. J Craniomaxillofac Surg 2015;43(4):491-6.

Lee ST, Park JH, Kwon TG. Influence of mandibular setback surgery on three-dimensional pharyngeal airway changes. Int J Oral Maxillofac Surg 2019;48(8):1057-65.

Shah DH, Kim KB, McQuilling MW, Movahed R, Shah AH, Kim YI. Computational fluid dynamics for the assessment of upper airway changes in skeletal Class III patients treated with mandibular setback surgery. Angle Orthod 2016;86(6):976-82.

Schwab RJ, Pasirstein M, Pierson R, Mackley A, Hachadoorian R, Arens R, et al. Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am J Respir Crit Care Med 2003;168(5):522-30.

Guijarro-Martínez R, Swennen GR. Cone-beam computerized tomography imaging and analysis of the upper airway: a systematic review of the literature. Int J Oral Maxillofac Surg 2011;40(11):1227-37.

Momany SM, AlJamal G, Shugaa-Addin B, Khader YS. Cone beam computed tomography analysis of upper airway measurements in patients with obstructive sleep apnea. Am J Med Sci 2016;352(4):376-84.

Ghoneima A, Kula K. Accuracy and reliability of cone-beam computed tomography for airway volume analysis. Eur J Orthod 2013;35(2):256-61.

Joosten SA, O’Driscoll DM, Berger PJ, Hamilton GS. Supine position related obstructive sleep apnea in adults: pathogenesis and treatment. Sleep Med Rev 2014;18(1):7-17.

El H, Palomo JM. Measuring the airway in 3 dimensions: a reliability and accuracy study. Am J Orthod Dentofacial Orthop 2010;137(Suppl 4):S50-2.

Kim S-J, Kim KB, editors. Orthodontics in obstructive sleep apnea patients: a guide to diagnosis, treatment planning, and interventions. 1st ed. Cham,CH: Springer; 2019.p.6-7

El Shayeb M, Topfer LA, Stafinski T, Pawluk L, Menon D. Diagnostic accuracy of level 3 portable sleep tests versus level 1 polysomnography for sleep-disordered breathing: a systematic review and meta-analysis. CMAJ 2014;186(1):E25-51.

Wang T, Yang Z, Yang F, Zhang M, Zhao J, Chen J, et al. A three dimensional study of upper airway in adult skeletal Class II patients with different vertical growth patterns. PLoS One 2014;9(4):e95544.

Chiang CC, Jeffres MN, Miller A, Hatcher DC. Threedimensional airway evaluation in 387 subjects from one university orthodontic clinic using cone beam computed tomography. Angle Orthod 2012;82(6):985-92.

Alves PV, Zhao L, O’Gara M, Patel PK, Bolognese AM. Threedimensional cephalometric study of upper airway space in skeletal Class II and III healthy patients. J Craniofac Surg 2008;19(6):1497-507.

Desai R, Komperda J, Elnagar MH, Viana G, Galang-Boquiren MTS. Evaluation of upper airway characteristics in patients with and without sleep apnea using cone-beam computed tomography and computational fluid dynamics. Orthod Craniofac Res 2023;26 (Suppl 1):164-70.