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Orthodontic tooth movement is caused by the force acting on the periodontal tissue surrounding the tooth that divides by the affected area into two sides: the side that a tooth moves toward is called the pressure side; the other side is the opposite side that a tooth moves away from, called the tension side. These sides present periodontal tissue remodeling from the stimulation of various mediators such as cytokines, growth factors, and chemokines. Chemokines are small molecules that are important for bone remodeling processes in orthodontic tooth movement. This review article aims to present the role and importance of chemokines in orthodontic tooth movement.
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