Distraction Osteogenesis in Cleidocranial Dysostosis: A Case Report

Main Article Content

Wipapun Ritthagol
Thongchai Nuntanaranon


Cleidocranial dysostosis is one of the congenital deformities that involved both teeth and their bone support. The deformities often present with complexity of disorder in the multiple regions. Base on the clinical evidence, the result of orthodontic treatment providing in the younger age groups revealed better outcome than in the older age patient groups. In addition, the treatment protocols are varied depend on the severity of deformities, age, developmental stage of the permanent dentition, periodontal status and budgets of treatment due to the long and multiple surgical operations. The orthodontic treatment protocol of cleidocranial dysplasia in the growing age could be started with the selected serial extraction of the deciduous teeth and removed the supernumerary teeth. This performance stimulates the spontaneous eruption of related permanent teeth to erupt in the alveolar bone with the proper position. The unerupted permanent teeth could only be achieved by artificial orthodontic force. The permanent dentition then will be aligned to get the optimal occlusion. Nevertheless, the surgical operation of jaw bones may be needed especially in patients with severe discrepancy of bony structures that beyond the orthodontic compensation. These guidelines of treatment provided the satisfied outcome of occlusion, masticatory function and facial esthetics in cleidocranial dysostosis patients.

Article Details

How to Cite
Ritthagol W, Nuntanaranon T. Distraction Osteogenesis in Cleidocranial Dysostosis: A Case Report. Thai J Orthod [Internet]. 2024 Apr. 16 [cited 2024 May 21];14(1):31-40. Available from: https://he01.tci-thaijo.org/index.php/THAIORTHO/article/view/260599
Case Report


Roberts T, Stephen L, Beighton P. Cleidocranial dysplasia: A review of the dental, historical, and practical implications with an overview of the South African experience. Oral Sur Oral Med Oral Pathol Oral Radiol 2013;115(1):46-55.

Bufalino A, Paranaı´ba LMR, Gouvêa AF, Gueiros LA, Martelli-Júnior H, Junior JJ, et al. Cleidocranial dysplasia: oral features and genetic analysis of 11 patients. Oral Dis 2012;18(2):184-90.

Cooper SC, Flaitz CM, Johnston DA, Lee B, Hecht JT. A natural history of cleidocranial dysplasia. Am J Med Genet 2001;104(1):1-6.

Kreiborg S, Jensen BL, Larsen P, Schleidt DT, Darvann T. Anomalies of craniofacial skeleton and teeth in cleidocranial dysplasia. J Craniofac Genet Dev Biol 1999;19(2):75-9.

Martins RB, de Souza RS, Giovani EM. Cleidocranial dysplasia: Report of six clinical cases. Spec Care Dent 2014;34(3):144-50.

Jensen BL, Kreiborg S. Craniofacial growth in cleidocranial dysplasia--a roentgencephalometric study. J Craniofac Genet Dev Biol 1995;15(1):35-43.

Jensen BL, Kreiborg S. Development of the dentition in cleidocranial dysplasia. J Oral Pathol Med 1990;19(2):89-93.

Atasu M, Dumlu A, Ozbayrak S. Multiple supernumerary teeth in association with cleidocranial dysplasia. J Clin Pediatr Dent 1996;21(1):85-91.

Golan I, Baumert U, Hrala BP, Müssig D. Dentomaxillofacial variability of cleidocranial dysplasia: Clinicoradiological presentation and systemic review. Dentomaxillofac Radiol 2003;32(6):347-54.

Becker A, Lustmann J, Shteyer A. Cleidocranial dysplasia: part 1--general principles of the orthodontic and surgical treatment modality. Am J Orthod Dontofacial Orthop 1997;111(1):28-33.

Frota CM, Pinherio FHSL, Caetano IM, Carvalho RM, Aiello CA. Interdisciplinary treatment of patients with cleidocranial dysplasia and multiple unerupted permanent teeth. J Clin Orthod 2021;55(11):1-13.

Ho CY, Ko EWC, Lin CH. Long-term observation of orthodontic management and facial growth on a patient with familial cleidocranial dysplasia. Taiwanese J Orthod 2019;31(4):226-40.

Jensen BL, Kreiborg S. Development of the dentition in cleidocranial dysplasia. J Oral Patho Med 1990;19(2):89-93.

Becker A, Shteyer A, Bimstein E, Lustmann J. Cleidocranial dysplasia: part 2--treatment protocol for the orthodontic and surgical modality. Am J Orthod Dentofacial Orthop 1997;111(2):173-83.

Bechtold TE, Lee KJ, Park YC, Berneburg M, Göz GR. A simultaneous mobilization of four impacted upper incisors in a case of an adolescent patient with cleidocranial dysplasia (CCD). Dentistry 2014;4(3):1000210.

Zhu Y, Zou Y, Yu Q, Sun H, Mou S, Xu S, et al. Combined surgicalorthodontic treatment of patients with cleidocranial dysplasia: case report and review of the literature. Orphanet J Rare Dis 2018;13(1):217.

Ritthagol W, Supakanjanakant D, Nuntanaranon T. Cleidocranial dysostosis. OJ Thai Assoc Orthod 2022;12(1):4-11.

Frame K, Evans RI. Progressive development of supernumerary teeth in cleidocranial dysplasia. Br J Orthod 1989;16(2):103-6.

Farrow E, Nicot R, Wiss A, Laborde A, Ferri J. Cleidocranial dysplasia: a review of clinical, radiological, genetic implications and a guidelines proposal. J Craniofac Surg 2018;29(2):382-9.

Manjunath K, Kavitha B, Saraswathi TR, Sivapathasundharam B, Manikandhan R. Cementum analysis in cleidocranial dysostosis. Indian J Dent Res 2008;19(3):253-6.