Effect of Ibuprofen on Orthodontic Tooth Movement

Abstract

Orthodontic tooth movement is a consequence of mechanical forces that are induced by orthodontic appliances. In order to generate and propagate the signaling cascades through all paradental tissue cells, the inflammatory processes are occurred by increasing the blood flow in the PDL space and local vessels. The expression of proinflammatory cytokines mediator induces the inflammatory pain sensitization. Pharmacological administration of analgesics is still a common method that is used for pain control. Ibuprofen is the commonly used drugs for moderate pain control in dentistry. Ibuprofen is a nonsteroidal anti-inflammatory drug that has an effect on bone remodeling. This review aims to explain the effects of Ibuprofen on orthodontic tooth movement.