Trastuzumab deruxtecan for treated HER2-low advanced breast cancer
Keywords:
trastuzumab deruxtecan, HER2 low breast cancer, HER2-directed antibody drug conjugatesAbstract
Breast cancer is the most prevalent cancer diagnosis and is the second leading cause of cancer-related deaths in women. Patients with HER2 protein overexpression or HER2 positive status benefit from HER2 inhibitors, including those with HER2 low breast cancer, Trastuzumab deruxtecan, classified as HER2-directed antibody drug conjugates (ADCs), deliver cytotoxic agents to cancer cells. Trastuzumab deruxtecan is FDA-approved for adult patients with unresectable or metastatic HER2-low breast cancer who have received prior chemotherapy. The recommended dose is 5.4 mg/kg given intravenously every 3 weeks.Common adverse reactions include nausea, vomiting, decreased appetite and anemia.
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