Thai cancer journal

Precision Medicine and Cancer

2024-12-17T15:56:43+07:00

Precision medicine in oncology represents a modern approach that tailors diagnosis and treatment to the specific characteristics of each patient. This strategy involves providing effective medications at the most appropriate doses and times, personalized for each individual. The analysis of molecular profiles, such as genetic, proteomic, and metabolomic data from cancer samples, combined with patient health data, is essential for identifying potential therapeutic targets and guiding the monitoring of targeted treatments. Advanced technologies like whole-genome sequencing, RNA sequencing, behavioral data, environmental factors, and comprehensive health data are critical tools that help physicians make informed decisions and improve treatment outcomes for cancer patients. Precision medicine also extends to supportive care, enhancing the prognosis of patients with malignancies. However, access to this approach may be limited in certain areas due to a lack of advanced technology and specialized expertise. Despite these challenges, precision medicine remains a promising trend that aims to improve patient-specific care and treatment by utilizing individualized health data to maximize the effectiveness of current therapeutic interventions.

Health Literacy of Gynecological Cancer Patients Experiencing Numbness in Hands and Feet Due to Receiving Paclitaxel Chemotherapy

2025-03-12T08:26:51+07:00

This descriptive study aimed to examine the health literacy regarding self-care practices for managing experiencing of numbness in the hands and feet due to receiving Paclitaxel chemotherapy at LopBuri Cancer Hospital. The study sample consisted of 81 female gynecologic cancer patients aged 18 and above, who were receiving Paclitaxel chemotherapy and experienced symptoms of numbness in the hands and feet. Data were collected using a questionnaire developed by the researcher, based on a review of relevant literature and theories, as well as the Health Literacy Assessment Tool, which consisted of six steps from the Health Education Division, Department of Health Service Support, Ministry of Public Health. The instrument demonstrated high content validity (IOC = 0.98) and reliability (Cronbach’s Alpha Coefficient = 0.94). The data collection period was from May to August 2024. Descriptive statistics and the Spearman’s rank correlation coefficient were used for data analysis. The study results indicated that there was no significant relationship between the participants' health literacy regarding access to information and health services, understanding information and services, verifying information, communication and social support, and self-management in alleviating the severity of numbness in the hands and feet due to Paclitaxel chemotherapy (r=-0.089, P=0.429) This study provides foundational information for designing strategies to improve health literacy among gynecologic cancer patients undergoing Paclitaxel chemotherapy. The findings highlight the need for guidance and support to enhance patients' awareness and management of numbness in hands and feet, helping to prevent complications, and ensure patients can manage their symptoms effectively. The results also serve as a basis for healthcare providers to promote appropriate health literacy and increase access to quality health services for patients.

The Effectiveness of Using Work Instruction: Nursing Care of Total Abdominal Hysterectomy with Bilateral Salpingo-Oophorectomy (TAH&BSO) Surgery Patients for the Prevention of Postoperative Complications Lopburi Cancer Hospital

2025-03-12T08:01:38+07:00

This quasi-experimental research aimed to compare the effects of nursing interventions for patients who underwent Total Abdominal Hysterectomy with Bilateral Salpingo-Oophorectomy (TAH&BSO) to prevent postoperative complications. The study was conducted with two groups: an experimental group that received the nursing intervention, and a control group that received standard care. The sample consisted of 32 female patients who underwent TAH&BSO in the surgical ward at Lopburi Cancer Hospital, divided into two groups of 16 patients each. The research was conducted from June 1 to May 31, 2024. The research instruments included two parts: 1) a general information record form, which covered age, underlying diseases, nutritional status, disease diagnosis, disease stage, surgery duration, blood loss during surgery, anesthesia types, surgical wound types, and length of hospital stay, and 2) a record of postoperative complications, including hemorrhage, surgical wound infection, urinary tract infection, postoperative pain, and pneumonia. The nursing interventions for patients who underwent TAH&BSO to prevent postoperative complications. The content validity evaluation by experts (Content Validity Index: CVI) of 0.98. Descriptive statistics such as frequencies, percentages, means, and standard deviations, along with inferential statistics using Fisher's exact test, were used to compare postoperative complications between the experimental and control groups. The results revealed that no postoperative complications occurred in the experimental group, whereas 31.3% of the control group experienced complications, with significant differences between the two groups (P<.05). The complications in the control group included surgical wound infection (12.5%), urinary tract infection (6.3%), and pneumonia (8.3%). In conclusion, the nursing interventions for patients who underwent TAH&BSO to prevent postoperative complications led to improved postoperative care, preventing complications and enhancing patient outcomes. This study contributes to the development of nursing practices aimed at preventing postoperative complications following TAH&BSO at Lopburi Cancer Hospital.

Quality of Life in Advanced Breast Cancer Patients Receiving Chemotherapy in SuratThani Cancer Hospital

2025-07-09T23:17:34+07:00

Breast cancer is the most common cancer found in female patients worldwide. According to global cancer statistics for 2022, there were nearly 20 million new cancer cases globally, with breast cancer accounting for 11.6%. In Thailand, according to a statistical report from the Health Data Center (HDC) in 2022, there were 38,555 cases of breast cancer. At the provincial level, based on data from SuratThani Cancer Hospital during the 5-year period (fiscal years 2020–2024), there were a total of 2,653 new cases. Breast cancer significantly impacts both the physical and mental health of women. Therefore, the researcher conducted this study with the objectives of examining the quality of life in advanced breast cancer patients receiving chemotherapy, and studying the problems, needs, and opinions regarding the promotion of their quality of life. This study employed a mixed-methods approach, combining both quantitative and qualitative methods using the same purposively selected sample group of 110 participants. A breast cancer-specific quality of life measurement scale and an interview form were used. Data were analyzed using frequencies, percentages, means, standard deviations, and content analysis. The findings indicated that mixed-methods research, combining both quantitative and qualitative approaches, yielded more complete results than single-method research. Specifically, the quantitative findings based on the 5 dimensions of the quality of life measurement scale showed an overall moderate level of quality of life, with a score of 59.655 (41.43%). The qualitative findings provided data in 3 dimensions: 5 problem areas, 4 identified needs, and 3 opinions regarding quality of life promotion. These findings enhanced the comprehensiveness of the study and increased the practical value of the results. The quantitative research assessed quality of life in cancer-specific aspects, while in the qualitative research, participants described illness in terms of physical symptoms and emotional suffering. The quantitative research did not include economic aspects, whereas the qualitative findings revealed economic issues as significant problems contributing to greater hardship among many patients and significantly impacted their quality of life.

Effects of The I (Love U)-131 Performance Program on Thyroid Cancer Patients Treated with Radioiodine Ablation (I-131)

2025-09-27T14:06:19+07:00

This quasi-experimental research aimed to examine the effects of the I (Love U)-131 Program on self-care competence among thyroid cancer patients receiving iodine-131 therapy at Lopburi Cancer Hospital. The objectives were to compare the patients’ self-care knowledge and self-care behaviors between those who received the I (Love U)-131 Program and those who received routine nursing care. The sample consisted of 74 thyroid cancer patients who were admitted for iodine-131 therapy at Lopburi Cancer Hospital, Muang District, Lopburi Province. Participants were purposively selected and divided into two groups: a control group (n=37) receiving routine nursing care, and an experimental group (n=37) receiving nursing care using the I (Love U)-131 Program. The research instruments included (1) a general information questionnaire, (2) a self-care knowledge test for thyroid cancer patients during hospitalization and after discharge, (3) an observation form for self-care behaviors during hospitalization, and (4) a follow-up self-care behavior form on day 7 after discharge. Data were analyzed using descriptive statistics, including frequencies, percentages, means, and standard deviations. The Mann–Whitney U test was used to compare mean scores of knowledge and self-care behaviors between groups. The results revealed that the experimental group had significantly higher mean scores of self-care knowledge than the control group (P<.001). Similarly, the experimental group showed significantly higher mean scores of self-care behaviors than the control group (P<.001). The findings indicate that the I (Love U)-131 Program effectively enhanced self-care competence among thyroid cancer patients receiving iodine-131 therapy.

Adenoid Cystic Carcinoma of The Breast: A Case Report

2025-07-23T21:21:01+07:00

Adenoid cystic carcinoma (ACC) is an extremely rare tumor of the breast, accounting for approximately 0.1% of all cases of mammary malignancies. It is characterized by a slow-growing nature and an excellent prognosis, in contrast to most other forms of breast cancer. Diagnostic mammography and breast ultrasound play essential roles in the early detection and diagnosis of this uncommon tumor. Treatment options include lumpectomy with radiation therapy or mastectomy. Although late recurrence and distant metastasis have been reported in the literature, long-term surveillance remains crucial. This report describes the case of a 58-year-old woman with abnormal findings on screening mammography and ultrasonography, which were pathologically confirmed as adenoid cystic carcinoma of the breast, and includes a relevant literature review.