Expression of metastasis suppressor 1 is associated with clinical data and overall survival of breast cancer patients

Authors

  • Nuntana Meesiripan สถาบันมะเร็งแห่งชาติ
  • Anong Tepsuwan สถาบันมะเร็งแห่งชาติ

Keywords:

MTSS1 gene expression, ฺBreast Cancer, Overall survival

Abstract

Metastasis suppressor 1 or MTSS1 is a protein that plays an important role in cancer suppressor to metastasis. It is not currently known how MTSS1 controls cancer cells. Therefore, this study aimed to determine the association of MTSS1 gene expression with sex, age, pathological characteristics, cancer stage, metastasis, and overall survival. The expression of the MTSS1 gene was studied in 118 female fresh tissue samples with breast cancer aged 34-82 years (mean 53.2+9.8 years). Pathological characteristics of fresh tissue samples were; invasive ductal carcinoma as 105 samples (88.98%) of all fresh tissue samples by TaqMan real-time PCR technique. Survival of patients was monitored from medical records, and civil registry. An analysis of the association with various variables showed that MTSS1 gene expression increased from 0.003-19.284 times compared with beta-actin (internal control) gene. In 84 samples, MTSS1 expression increased as 1.83±2.89 fold, and fresh tissue samples from patients with stage 3 and 4 cancer showed a 1.98±3.65 times increase in MTSS1 gene expression. The expression of the MTSS1 gene was slightly greater in patients with advanced cancer (stage 3 and 4) than in the first stage (stage 1 and 2), but there was no statistically significant difference (P=0.899).Cancer metastasis as 19 samples (16.10%) increased MTSS1 expression than the group without metastasis. However, there was no statistically significant difference (P=0.413). The MTSS1 gene expression was found in patients with less than or equal to 60-month survival rate and more than 60-month survival rate. There was a statistically significant difference (P=0.048), so it was concluded that MTSS1 expression was not associated with age pathological characteristics and cancer metastasis, but correlated with overall survival.This result may be used to predict further or prognosis the survival rate of breast cancer.

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Published

2021-08-21

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