Evaluation of vitronectin expression levels from breast cancer patients with different stages

  • Jarunya Ngamkham National Cancer Insitute , Thailand
  • Somchai Thanasitthichai Institute of Medical Research and Technology Assessment, Department of Medical Service, Ministry of Public Health
  • Aree Prasitthipayong National Cancer Insitute , Thailand
  • Anupong Chaiyamol National Cancer Insitute , Thailand
  • Maneerut Mas-u-dee
  • Kittika Boonmark
  • Thainsang Phansri
Keywords: มะเร็งเต้านม vitronectin CEA CA15-3

Abstract

Breast cancer is the most common cancer in women worldwide. Currently, there is no specific biomarker for early diagnosis. The identification of potential biomarkers for early detection will ensure a good prognosis and improve the clinical outcome. Vitronectin (VN) is a glycoprotein involved in multifunctional roles in inflammation, cell adhesion, and migration. There are some evidences showed that VN levels were elevated in some cancers, including breast cancer. This study aimed to investigate a new biomarker's efficiency as VN in the early stage of breast cancer. Serum and plasma of VN were collected from 112 breast cancer patients with different stages and 13 healthy women by enzyme-linked immunosorbent assay (ELISA). The clinical biomarkers of breast cancer as CEA and CA15-3 were used as references. The results showed that serum and plasma VN levels were elevated in breast cancer patients with stage II higher than VN levels in other stages. Whereas serum CEA and CA15-3 levels exhibited higher expression levels in serum from breast cancer patients with advanced-stage (II-IV) than early-stage (0-II). However, both clinical biomarkers, CEA, CA15-3 and VN expression levels from the serum of healthy women, showed low expression levels.The area under the curve (AUC) of ROC was also used to determine the efficiency of VN, found that AUC to be about 0.629 with a P<0.05 in breast cancer with early stage. In conclusion, serum and plasma VN may be promising diagnostic biomarkers that can be detected in the serum and plasma of breast cancer patients with early stage. While serum CEA and CA15-3 were useful markers for predicting aggressive cancer in the advanced stage.

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Published
2021-05-08
Section
Original Articles