Utility of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Prognostic Factors in Pretreatment Breast-cancer Patients

  • Suchanuch Ondee National Cancer Insitute , Thailand
Keywords: breast cancer, prognosis, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio


Breast cancer is the most frequently diagnosed and leading cause of cancer deaths among females worldwide. Neutrophils are one of the immune cells involved in the inflammatory process related to the cause of cancer. The aim of the present study was to utilize the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic factors in breast cancer patients. The medical records of 434 breast cancer patients diagnosed at the National Cancer Institute between 1997 and 2017 were reviewed. The results showed that     the mean age of the patients was 50.76 years (SD=10.76). The NLR and PLR were 0.61–15.61 (mean 2.49±1.77) and 3.48–99.18 (mean 11.51±8.12), respectively. The findings from multivariate analysis revealed that high NLR (≥2) and high PLR (≥9.4) were not related to the overall survival of breast-cancer patients. In addition, we found that patients with lymph-node metastasis, negative PR and positive HER-2 had significantly poorer survival rates than the reference group (hazard ratio=6.6, 3.2 and 3.4; P=0.001, 0.007 and 0.023, respectively); no association was found between the other prognostic factors and survival. This   study suggests that NLR and PLR were not prognostic factors for breast-cancer   patients.


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