Overall Survival and Prognostic Factors for Breast Cancer Patients at Vachira Phuket Hospital

Abstract

This retrospective study analyzed the 5-year survival rate and prognostic factors among breastcancer patients at Vachira Phuket Hospital, Thailand. The study included 253 new female breast cancer patients diagnosed during the period 1 January 2007 to 31 December 2011 and followed up until the end of 2015. The clinico-pathological data of the patients were collected for evaluation. It was found that 83 cases (32.80%) had died and 170 cases (67.2%) were still alive. The overall survival rate at 5 years was 65.5%. The 5-year survival rates for stages I, II, III, and IV were 82.4%, 79.2%, 45.3% and 0%, respectively. When analysis was conducted by stages combined into 2 groups--early (stages I and II) and late (stages III and IV)--the 5-year survival rate for early stage (80.3%) was higher than for late stage (43.2%) (P<0.001). Patients with late stage (III and IV) showed higher rate of death than early stage (I and II)( (hazard ratio=3.922; P<0.001). Patients with luminal B and triple negative subtypes had shorter survival times than luminal A subtype (P<0.05). In addition, the findings showed that the stages at diagnosis and metastasis affected patient survival rate. The adjusted hazard ratio of patients with stage III and IV were 4.1 (P=0.003) and 11.86 (P<0.001), respectively, compared with stage I. Patients with metastasis had an adjusted hazard ratio of 2.72 (P<0.001), compared with the non-metastatic group. These findings indicate that early diagnosis increased overall survival rates among breast-cancer patients.