Factors Associated with Colonic Polyp Detection in Asymptomatic Patients
Keywords:
CEA, colonic polyp, dysplasia grading, colorectal cancerAbstract
Currently, increasing numbers of people are seeking medical advice for screening colorectal cancer. One of the reasons for patients' deciding to undergo colonoscopic examinations has been the detection of high serum carcinoembryonic antigen (CEA) levels. This study aimed to evaluate the factors associated with the detection of colonic polyps and the association between high CEA level and type, number, and dysplastic grading of polyps. This was a cross-sectional descriptive study of asymptomatic patients who visited the gastrointestinal clinic at Lopburi Cancer Hospital for annual check-ups, from July 2015 to July 2017. In all, 238 patients (118 male; 120 female) were included. The mean patient age+ standard deviation was 58.1+10.6 years. The results showed elevated CEA level was more common in the male group than the female group (62.8 and 37.2%, respectively; P=0.004). Elevated CEA level was statistically significantly higher in the smoking group than the non-smoking group (P=0.000). In addition, the ages of the group without polyps were younger than the other groups (non-advanced adenoma, advanced adenoma, and malignancy groups) (55.08+10.7, 59.34+9.35, 64.39+9.16, and 62.00+4.96 years, respectively, P=0.000). Regarding CEA level, a normal colonoscopy finding mainly (60.6%) occurred in the normal CEA level group. Nevertheless, more patients with non-advanced adenoma, advanced adenoma, and malignancy, had elevated CEA levels (37.2%, 17.9%, and 6.4%, respectively) than groups with normal CEA (24.4, 14.4, and 0.6, respectively, P=0.002). CEA level did not correlate with number of adenomatous polyps (P=0.959). However, elevated CEA was associated with high-grade dysplasia of adenomatous polyps (P=0.039).
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