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Links between Gut bacteria, Prebiotic and Reduction in Risk of Alzheimer’s Disease in Elderly
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Published:
Nov 24, 2021
Versions:
2021-11-24 (1)
Keywords:
Gut microbiota /Alzheimer’s disease / gut-brain axis/ prebiotic
Main Article Content
Abstract
The alteration of gut microbial composition or gut dysbiosis in elderly adults can cause Alzheimer’s disease which is related to directional gut-brain axis communication. Some bacteria can produce neurotoxin metabolite products in the gut such as lipopolysaccharide (LPS), β-N-methylamino-L-alanine (BMMA) and β-amyloids which affect the inflammation and neuron impairment in the central nervous system (CNS) via various pathways. Prebiotic or fiber consumption from vegetables, fruits, and cereals can activate short-chain fatty acid bacteria or probiotic bacteria. They can produce anti-inflammation metabolites and decrease the epithelial permeability of neurotoxic metabolites. Consequently, these may prevent the risk of Alzheimer’s disease which cause by gut dysbiosis in the elderly.
Article Details
How to Cite
Kongchai, T. (2021). Links between Gut bacteria, Prebiotic and Reduction in Risk of Alzheimer’s Disease in Elderly. Thai Journal of Safety and Health, 15(1), 1–9. retrieved from https://he01.tci-thaijo.org/index.php/JSH/article/view/247630
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Academic Article
Journal of Safety and Health is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence, unless otherwise stated.
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อัญชลี ศรีจำเริญ.(2561). อาหารและโภชนาการ การป้องกันกลไกบกพร่อง.กรุงเทพมหานคร: สำนักพิมพ์
แห่งจุฬาลงกรณ์มหาวิทยาลัย.
Busnelli, M., Manzini, S., & Chiesa, G. (2020). The Gut Microbiota Affects Host
Pathophysiology as an Endocrine Organ: A Focus on Cardiovascular Disease. Nutrients. 12(79), 1-32.
Carabotti, M., Scirocco, A., Maselli, M.A. & Severi, C. (2015). The gut-brain axis:
interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology. 28(2), 203-209.
Conte, C., Sichetti, M. & Traina, G. (2020). Gut–Brain Axis: Focus on neurodegeneration
and mast cells. Applied Sciences. 10 (1828), 2-19.
Dinan, T.G., Stilling, R.M., Stanton, T. & Cryan, J.F. (2015). Collective unconscious: How
gut microbes shape human behavior. Journal of Psychiatric Research. 63(2015), 1-9.
Dalile, B., Oudenhove, L.V., Vervliet, B. & Verbeke, K. (2019). The role of short- chain
Fatty acids in microbiota–gut–brain communication. Nature Reviews gastroenterology & hepatology. 16 (2019): 461-478.
Kowalski, K & Mulak, A. (2019). Brain-gut microbiota axis in Alzheimer’s disease. Journal of
neurogastroenterol Motil. 25(1), 48-60.
Lina, C., Zhao, S., Zhua, Y., Fana, Z., Wang, J., Zhang, B. & Chen, Y. (2019). Microbiota-
gut-brain axis and toll-like receptors in Alzheimer’s disease. Computational and Structural Biotechnology Journal. 17 (2019), 1309–1317.
Long, J.M. &Holtzman, D.M. (2019). Alzheimer Disease: An Update on Pathobiology and Treatment
Strategies. Cell. 179(2), 312-339.
Parker, A., Fonseca, S. & Carding, S.R. (2020). Gut microbes and metabolites as modulators
of blood-brain barrier integrity and brain health. Gut Microbes. 11(2), 135–157.
Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G.A.D., Gasbarrini, A.&
Mele, M.C. (2019). What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. 7(14), 17-22.
Sarkar, S.R. & Banerjee, S. (2019). Gut microbiota in neurodegenerative disorders. Journal
of Neuroimmunology. 328 (2019), 98–104.
Silva, Y.P., Bernardi, A. & Luiz, R. (2020). The role of short-chain fatty acids from gut
microbiota in gut-brain communication. Frontiers endocrinology. 11(2020), 1-14.
Thursby, E. & Juge, N.(2017). Introduction to the human gut microbiota. Biochemical
Journal. 474(11), 1823–1836.
Vinolo, M.A.R., Rodrigues, H.G., Nachbar, R.T. & Curi, R. (2011). Regulation of
inflammation by short chain fatty acids. Nutrients. 3(10), 858-876.
Westfall, S., Lomis, N., Kahouli, I., Dia, S.Y., Singh, S.P. & Prakash, S. (2017).
Microbiome, probiotic and neurodegenerative diseases deciphering the gut brain axis. Cellular and Molecular Life Sciences. 2017 (74), 3769-3787.
Wu, W., Kong, Q., Tian, P., Zhai, Q., Wang, G., Liu, X., Zhao, J., Zhang, H., Lee, Y.K. &
Chen, W. (2020). Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders. Engineering. 6(4), 415-423.
Zhao, Y., Jaber, V. & Lukiw, W.J. (2017). Secretory products of the human GI tract
microbiome and their potential impact on Alzheimer's disease (AD): Detection of lipopolysaccharide (LPS) in AD hippocampus. Front Cellular and Infection Microbioly. 7(318): 1-9.