Links between Gut Bacteria, Prebiotic, and Reduction in Risk of Alzheimer’s Disease in the Elderly
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Abstract
The alteration of gut microbial composition or gut dysbiosis in the elderly can cause Alzheimer’s disease which is related to directional gut-brain axis communication. Some bacteria can produce neurotoxin metabolite products in the gut which affect the inflammation and neuron impairment in the central nervous system (CNS) through various pathways. Diet is the significant factor that affects the conversion of gut bacteria composition. Prebiotics or fiber consumption from vegetables, fruits, and cereals can activate short-chain fatty acid bacteria or probiotic bacteria. They can produce anti-inflammation metabolites and decrease the epithelial permeability of neurotoxic metabolites. Understanding the association between gut bacteria, prebiotic, and Alzheimer’s disease should provide the guideline to prevent the risk of Alzheimer’s disease which causes by gut dysbiosis in the elderly.
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