Comparative hypotension effect between low dose and high dose crystalloid co-load in parturient under spinal anesthesia for elective cesarean section


  • Jarunee Rakkarnngan Department of Anesthesiology, Phra Nakhon Si Ayutthaya Hospital


Hypotension, Parturient, Crystalloid co-load, spinal anesthesia


Hypotension effect from spinal anesthesia is a common side effect in general practice.This study aim to compare the efficacy of crystalloid co-load high dose and low dose for preventing of hypotension effect in parturient under spinal anesthesia for elective cesarean section.

          This randomized control trial was conducted in operating room of Phra Nakhon Si Ayutthaya Hospital. The study was carried out from July 2020 to January 2021.Inclusion criteria were parturient with singleton fetus GA more than 37 weeks, age 15-45 years old, body weight no more than 100 Kgs, ASA classification I-II who had elective cesarean section under spinal anesthesia, no previous hypertension history before or during pregnancy period . All 60 patients were divided into two group, group H received 15 ml/kg of crystalloid co-load and group L received 10 ml/kg of crystalloid co-load just after injected local anesthetic drug to subarachnoid space. The BP were recorded at 1, 2, 3, 5, 10 and 15 min after injection. Decreasing more than 20% of baseline BP was defined as Hypotension. The inotropic drug was given if SBP < 90 mmHg.

          Total study population was 60 parturient. There were no statistical difference between two group in the most demographic data. Mean age of patients was 29.79+/- 5.80 years in both group. Mean BW was 70.30+/- 12.68 Kgs and 76.63+/- 12.74 Kgs in group H and group L, respectively. After induction of spinal anesthesia hypotension was noted in both group.The difference between two group was statistical insignificantly at all of time recored.The 10 ml/kgs crystalloid co-load compared to 15 ml/kgs crystalloid co-load was not difference in prevent hypotension effect from spinal anesthesia in parturient who had elective cesarean section.


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How to Cite

Rakkarnngan จ. Comparative hypotension effect between low dose and high dose crystalloid co-load in parturient under spinal anesthesia for elective cesarean section. JPMAT [Internet]. 2022 Jan. 26 [cited 2022 Aug. 13];11(3):641-52. Available from:



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