Dyslipidemia in Chronic Kidney Disease
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Abstract
Dyslipidemia is a well-known traditional risk factor for cardiovascular disease that leads to an increase in morbidity and mortality among the general population and patients with kidney diseases. High prevalence of dyslipidemia is observed in patients with chronic kidney disease (CKD) and the degree of abnormality is highly related to the severity of CKD. In addition to diabetes, obesity and smoking, other factors that may influence dyslipidemia in CKD include uremic toxins, oxidative stress, endothelial dysfunction and renal replacement therapy. In addition to heightening the risk of cardiovascular disease, dyslipidemia may also increase the rate of progression of CKD. The levels of low-density lipoprotein (LDL) and other types of lipids including lipoprotein (a) and oxidized LDL are highly associated with cardiovascular disease. The mainstay for management of dyslipidemia in CKD includes modification of risk factors and the use of lipid lowering agents especially statins.
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