Development of a Model for Prevention and Control of Iron Deficiency Anemia in Health Region 8

Authors

  • Tanisa Anuyahong Health Promotion Center 8 Udon Thani, Department of Health, Ministry of Public Health, Mueang Udon Thani, Udon Thani, Thailand https://orcid.org/0009-0001-5591-9095
  • Kanyarat soimalai Health Promotion Center 8 Udon Thani, Department of Health, Ministry of Public Health, Mueang Udon Thani, Udon Thani, Thailand
  • Apichit sriouan Health Promotion Center 8 Udon Thani, Mueang Udon Thani, Udon Thani, Thailand
  • Duangjai kanthiya Health Promotion Center 8 Udon Thani, Department of Health, Ministry of Public Health, Mueang Udon Thani, Udon Thani, Thailand
  • Pornpimol Butala Health Promotion Center 8 Udon Thani, Department of Health, Ministry of Public Health, Mueang Udon Thani, Udon Thani, Thailand

Keywords:

Anemia, Health behavior, Research and Development, PRECEDE-PROCEED Model, Health Region 8

Abstract

Anemia is a significant public health concern in Health Region 8, Thailand, with prevalence rates of 29.5% among pregnant women, 20.5% among preschool children, and 37.6% among 6-year-old schoolchildren. This study aimed to develop and test a prevention and control program for anemia in Health Region 8 by integrating the four phases of the Research and Development (R&D) framework by Borg and Gall with the PRECEDE–PROCEED Model. Phase 1 assessed the situation through surveys of 839 service units across seven provinces and focus group discussions with 35 stakeholders, identifying four key barriers: inadequate screening coverage, lack of continuous follow-up systems, poor intersectoral coordination, and incorrect public knowledge and attitudes toward iron supplementation. Phase 2 developed the “R8 Iron MOM” program comprising five activities: anemia knowledge provision, iron-rich local food selection, proper iron supplementation techniques, health monitoring systems, and community-based support. Phase 3 tested the program using a one-group pretest-posttest design with 158 participants (pregnant women, children aged 6 months–5 years, and grade 1 students) over four weeks. Phase 4 evaluated and refined the program. Data were analyzed using paired t-tests and McNemar's tests. Results showed statistically significant improvement across all groups: mean hematocrit increased by 1.8–3.4% (p < 0.001, Cohen's d = 0.94–1.52), knowledge scores improved by 0.8–1.4 points (p < 0.001, Cohen's d = 0.91–1.65), and daily iron supplementation adherence increased from 46.8% to 89.2% (p < 0.001). Overall satisfaction was at the highest level (Mean = 4.2, SD = 0.7). The R8 Iron MOM program showed promising trends in improving hematocrit levels, knowledge, and iron supplementation behaviors; it may be adapted for other contexts with appropriate modifications. However, controlled trial designs are recommended to confirm effectiveness and establish causal relationships.

References

Wang R, Xu S, Hao X, et al. Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies. Front Glob Womens Health. 2025;6:1502585. doi: 10.3389/fgwh.2025.1502585.

Obianeli C, Afifi K, Stanworth S, Churchill D. Iron deficiency anaemia in pregnancy: A narrative review from a clinical perspective. Diagnostics (Basel). 2024;14(20):2306. doi: 10.3390/diagnostics14202306.

Obeagu EI. The impact of anemia on the immune system during pregnancy: a review. Int J Med Sci Pharma Res. 2025;11(1):28–33. Available from: https://ijmspr.in/index.php/journal/article/view/137.

Stevens GA, Paciorek CJ, Flores-Urrutia MC, et al. National, regional, and global estimates of anaemia by severity in women and children for 2000–19: a pooled analysis of population-representative data. Lancet Glob Health. 2022;10(5):e627–e639. doi: 10.1016/S2214-109X(22)00084-5.

Pongcharoen T, Rojroongwasinkul N, Tuntipopipat S, et al. South East Asian Nutrition Surveys II (SEANUTS II) Thailand: Triple burden of malnutrition among Thai children aged 6 months to 12 years. Public Health Nutr. 2024;27(1):e152. doi: 10.1017/S1368980024000053.

กรมอนามัย กระทรวงสาธารณสุข. รายงานประจำปี 2568 ระบบเฝ้าระวังการส่งเสริมสุขภาพและอนามัยสิ่งแวดล้อม กรมอนามัย. นนทบุรี: กองแผนงาน กรมอนามัย; 2569.

สุนิสา สถลนันท์, สายพิณ โชติวิเชียร, จันทร์อาภา สุขทัพภ์, วนิดา ชนันทยุทธวงศ์, นภาพรรณ วิริยะอุตสาหกุล. สถานการณ์ภาวะโภชนาการ ภาวะโลหิตจาง ระดับสติปัญญาในเด็กไทยวัยเรียน. วารสารส่งเสริมสุขภาพและอนามัยสิ่งแวดล้อม [Internet]. 2559 [cited 2025 Dec 19];39:62-75. Available from: https://he04.tci-thaijo.org/index.php/TJP/article/view/843.

ราชวิทยาลัยสูตินรีแพทย์แห่งประเทศไทย. การป้องกันและรักษาภาวะโลหิตจางในสตรีตั้งครรภ์ (Prevention and management of anemia in pregnancy) [Internet]. กรุงเทพฯ: ราชวิทยาลัยสูตินรีแพทย์แห่งประเทศไทย; 2023 [cited 27 มีนาคม 2026]. ค้นจาก: https://www.rtcog.or.th/files/1754468534_a1313bf4e47ba4bf4499.pdf

กรมอนามัย. คู่มือแนวทางควบคุมและป้องกันภาวะโลหิตจางจากการขาดธาตุเหล็ก [อินเทอร์เน็ต]. นนทบุรี: กรมอนามัย กระทรวงสาธารณสุข; 2563 [เข้าถึงเมื่อ 19 ธ.ค. 2568]. เข้าถึงได้จาก: https://nutrition2.anamai.moph.go.th/th/book/194488

Pasricha S R, Hayes E, Kalumba K, Biggs B A. Effect of daily iron supplementation on health in children aged 4–23 months: a systematic review and meta analysis of randomised controlled trials. Lancet Glob Health. 2013;1(2):e77–86. doi: 10.1016/S2214-109X(13)70046-9.

Wang L, Huo J, Wei Y, Tang Y, Sun J, Huang J. Yingyangbao reduced anemia among infants and young children aged 6-23 months when delivered through a large-scale nutrition improvement program for children in poor areas in China from 2015 to 2020. Nutrients. 2023;15(11):2634. doi: 10.3390/nu15112634.

Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale (NJ): Lawrence Erlbaum Associates; 1988. 590 p. (cited p.25).

World Health Organization. Intermittent iron supplementation in preschool and school-age children: guideline [Internet]. Geneva: World Health Organization; 2011 [cited 2025 Aug 20]. Available from: https://www.who.int/tools/elena/interventions/iron-intermittent-children

Andersen CT, Marsden DM, Duggan CP, Liu E, Mozaffarian D, Fawzi WW. Oral iron supplementation and anaemia in children according to schedule, duration, dose and cosupplementation: a systematic review and meta-analysis of 129 randomised trials. BMJ Glob Health. 2023;8(2):e010745. doi: 10.1136/bmjgh-2022-010745.

Borg WR, Gall MD. Educational research: An introduction. 4th ed. New York: Longman; 1983. 936 p. (cited p.775).

Gall MD, Gall JP, Borg WR. Applying educational research: A practical guide. 5th ed. Boston: Allyn & Bacon; 2003. 570 p. (cited pp. 563-576).

Green LW, Gielen AC, Ottoson JM, Peterson DV, Kreuter MW, editors. Health program planning, implementation, and evaluation: creating behavioral, environmental, and policy change. Baltimore: Johns Hopkins University Press; 2022. 488 p. (cited p.1-30).

Best JW, Kahn JV. Research in education. 10th ed. Boston: Pearson; 2006. 528 p. (cited pp. 200-246).

Kheirouri S, Alizadeh M. Process evaluation of a national school-based iron supplementation program for adolescent girls in Iran. BMC Public Health. 2014;14:959. doi: 10.1186/1471-2458-14-959.

Shao Y, Meng C, Liang Y. Digital versus non-digital health interventions to improve iron supplementation in pregnant women: a systematic review and meta-analysis. Front Med (Lausanne). 2024;11:1375622. doi: 10.3389/fmed.2024.1375622

World Health Organization. Global nutrition targets 2025: anaemia policy brief [Internet]. Geneva: World Health Organization; 2014 [cited 2025 Dec 20]. Available from: https://www.who.int/publications/i/item/WHO-NMH-NHD-14.4

Hasan MM, Soares Magalhaes RJ, Garnett SP, et al. Anaemia in women of reproductive age in low- and middle-income countries: progress towards the 2025 global nutrition target. Bull World Health Organ. 2022;100(3):196-204. doi:10.2471/BLT.20.280180.

Helmyati S, Lusmilasari L, Sandhi A, et al. Systematic review on supplementation, fortification, and food-based interventions for preventing iron deficiency anemia in low- and middle-income countries. Asia Pac J Clin Nutr. 2025;34(1):10-35. doi:10.6133/apjcn.202502_34(1).0002

Ali A, Khalid M, Sammar K, Fida N, Asmatullah A, Anwar S. Effectiveness and function of dietary and medical iron interventions in treating iron-deficiency anemia: a systematic review. Pak J Health Sci. 2025;6(4):308–315. doi: 10.54393/pjhs.v6i4.2979.

Haider BA, Olofin I, Wang M, Spiegelman D, Ezzati M, Fawzi WW. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2013;346:f3443. doi: 10.1136/bmj.f3443.

Chen Z, Yang H, Wang D, Sudfeld CR, Zhao A, Xin Y, Chen JC, Fawzi WW, Xing Y, Li Z. Effect of Oral Iron Supplementation on Cognitive Function among Children and Adolescents in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis. Nutrients. 2022; 14(24):5332. https://doi.org/10.3390/nu14245332.

Silitonga HTH, Salim LA, Nurmala I, Hargono R, Notobroto HB, Hartini N, Purwandini S. The role of social support and interpersonal trust to improve compliance of iron supplementation amongst adolescent girls: a qualitative approach. Niger Postgrad Med J. 2023;30(1):75–80. doi: 10.4103/npmj.npmj_277_22.

Hunter RF, de la Haye K, Murray JM, Badham J, Valente TW, Clarke M, Kee F. Social network interventions for health behaviours and outcomes: a systematic review and meta-analysis. PLoS Med. 2019;16(9):e1002890. doi: 10.1371/journal.pmed.1002890.

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Published

2026-04-06

How to Cite

Anuyahong, T., soimalai, K. ., sriouan, A., kanthiya, D., & Butala, P. (2026). Development of a Model for Prevention and Control of Iron Deficiency Anemia in Health Region 8. Journal of Nutrition Association of Thailand (Online), 61(1), 1–18. retrieved from https://he01.tci-thaijo.org/index.php/JNAT/article/view/283506

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Research article