Effects of Dark Chocolate with Cacao Beverages Consumption on Lipid Profiles in Healthy Volunteers

Authors

  • Nattakan - NIn-on Student
  • Promluck Sanporkha Department of Nutrition, Faculty of Public Health, Mahidol University
  • Chatrapa Hudthagosol Department of Nutrition, Faculty of Public Health, Mahidol University

Keywords:

Dark chocolate with cacao, Cacao powder, Lipid profiles

Abstract

Ischemic heart disease is one of the leading causes of death in Thailand and annual mortality trend from this disease has significantly increased. The common risk factors for coronary artery disease among Thais include dyslipidemia, hypertension, diabetes, stress, poor eating habits. Therefore, consuming healthy foods is one way to reduce the risk of this disease. This study aimed to examine the effects of dark chocolate and cacao beverages consumption on changes in lipid profiles among healthy subjects for 4 weeks. This randomized controlled trial included an experimental group (n=23) and placebo group (n=23). Paired t-test was used to compare changes of lipid profiles from week 0 to week 4 between experimental and placebo groups, Independent t-test was used to assess the differences in lipid profiles between the two groups. Results: Triglyceride and LDL-cholesterol concentrations significantly decreased from week 0 to 4 (p<0.05), while HDL-cholesterol concentration was dramatically higher at the week 4 than week 0 (p<0.000). However, the difference in total cholesterol concentration between week 0 and week 4 was not significant (p>0.05). Moreover, change in Triglyceride and HDL-cholesterol concentrations differenced significantly in experimental group compared to placebo group (p<0.05). In conclusion, this study found an advantage of dark chocolate with cacao beverages consumption on lipid profile in healthy volunteers.

References

กลุ่มข้อมูลข่าวสารสุขภาพ.อัตราตายจําแนกตามสาเหตุที่สําคัญ ต่อประชากร 100,000 คน ประเทศไทย พ.ศ. 2557 และ 2561. กรุงเทพมหานคร สถิติสาธารณสุข; 2561.

World Health Organization. Cardiovascular diseases [Internet]. 2017 [cited 2020 May 13]. Available from: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)

กองโรคไม่ติดต่อ กรมควบคุมโรค. ประเด็นสารรณรงค์วันหัวใจโลก [อินเตอร์เน็ต]. 2562 [ เข้าถึงเมื่อ 13 พฤษภาคม 2563]. เข้าถึงได้จาก: http://www.thaincd.com/document/file/download/knowledge/

สำนักโรคไม่ติดต่อ กรมควบคุมโรค กระทรวงสาธารณสุข. คู่มือประเมินและจัดการความเสี่ยงกลุ่มโรคหัวใจและหลอดเลือด [อินเตอร์เน็ต]. 2557 [เข้าถึงเมื่อ 13 พฤษภาคม 2563]. เข้าถึงได้จาก: http://thaincd.com/document/file/download/knowledge/

นิพนธ์ พวงวรินทร์. โกโก้กับสมอง. จุลสารเกลียวสัมพันธ์. 2559; 3:15-26.

กฤติยา ไชยนอก. โกโก้กับช็อคโกแลตวาเลนไทน์ [อินเตอร์เน็ต]. 2556: [เข้าถึงเมื่อ 24 สิงหาคม 2562]. เข้าถึงได้จาก: https://pharmacy.mahidol.ac.th/th/knowledge/article/132/

Badrie N, Bekele F, Sikora E, Sikora M. Cocoa agronomy, quality, nutritional and health aspects. Crit Rev Food Sci Nutr. 2015; 55:620-659.

Ndife J, Bolaji P, Atoyebi D, Umezuruike C. Production and quality evaluation of cocoa products (plain cocoa powder and chocolate). Am J Food Nutr. 2013; 3(1):31-38.

Ellinger S, Stehle P. Impact of cocoa consumption on inflammation processes A critical review of randomized controlled trials, Nutrients. 2016; 8(6):321.

Rostami A, Khalili M, Haghighat N, Eghtesadi S, Shidfar F, Heidari I et al. High-cocoa polyphenol-rich chocolate improves blood pressure in patients with diabetes and hypertension. ARYA Atheroscler. 2015; 11(1):21–29.

Osakabe N, Baba S, Yasuda A, Iwamoto T, Kamiyama M, Takizawa T et al. Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers. Free Radic Res. 2009; 34:93-99.

León-Flores P, Nájera N, Pérez E, Pardo B, Jimenez F, Diaz-Chiguer D et al. Effects of cacao by-products and a modest weight loss intervention on the concentration of serum triglycerides in overweight subjects: proof of concept. J Med Food. 2020; 1–5.

Tokede OA, Gaziano JM, Djousse L. Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis. Eur J Clin Nutr. 2011; 65:879-886.

Gutiérrez-Salmeán G, Ortiz-Vilchis P, M. Vacaseydel C, Rubio-Gayosso, Meaney E, Villarreal F et al. Acute effects of an oral supplement of (-)-epicatechin on postprandial fat and carbohydrate metabolism in normal and overweight subjects. Food Funct. 2014; 5(3):521–527.

Byrne A, Makadia S, Sutherland A, Miller M. Optimizing non-pharmacologic management of hypertriglyceridemia. Arch Med Res. 2017; 48(6):483–487.

Lippi G, Franchini M, Montagnana M, J.Favaloro E, Guidi GC, Targher G. Dark chocolate: consumption for pleasure or therapy?. J Thromb Thrombolysis. 2009; 28:482–488.

Katz DL, Doughty K, Ali A. Cocoa and chocolate in human health and disease. Antioxid Redox Signal. 2011; 15(10):2779-811.

Neufingerl N, Zebregs YE, Schuring EA, Trautwein EA. Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial. Am J Clin Nutr. 2013; 97(6):1201–9.

Wiryanthini IA D, IWG S, Yuliana. Cacao beans extract (Theobroma cacao L.) improve lipid profile but had no effect on blood nox concentration in dyslipidemia white male rat (Rattus norvegicus). J Biomed Sci. 2017; 11:1–5.

Agwupuye EI, Beshel JA, Anosike AC, U. Ezeanyika L. Methanol extract of unfermented Theobroma Cacao promotes normal lipid profile of wistar rats. IJTSRD. 2019; 3:190-193.

Jafarirad S, Ayoobi N, Karandish M, Jalali MT, Haghighizadeh MH, Jahanshahi A. Dark chocolate effect on serum adiponectin, biochemical and inflammatory parameters in diabetic patients: A randomized clinical trial. Int J Prev Med. 2018; 9:86.

Santos HO, Macedo RCO. Cocoa-induced (Theobroma cacao) effects on cardiovascular system: HDL modulation pathways. Clin Nutr ESPEN. 2018; 27:10-15.

Basu A, Betts NM, Leyva MJ, Fu D, Aston CE, Lyons TJ. Acute cocoa supplementation increases postprandial HDL-cholesterol and insulin in obese adults with type 2 diabetes after consumption of a high-fat breakfast. J Nutr. 2015; 145(10):2325-32.

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Published

2020-12-14

How to Cite

NIn-on, N. .-., Sanporkha, P., & Hudthagosol, C. (2020). Effects of Dark Chocolate with Cacao Beverages Consumption on Lipid Profiles in Healthy Volunteers. Journal of Nutrition Association of Thailand, 55(2), 52–61. Retrieved from https://he01.tci-thaijo.org/index.php/JNAT/article/view/244149

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Section

Research article