Roles of Maltrodextrin and Direct Compression Fillers in Formulation Development of Prasamawaeng Cough Tablets with and without Menthol II: Selection of Appropriate Formulations with Three Various Tastes

Abstract

          Objective: to select the formulas (R_xs) of Prasamawaeng cough tablets with citrus,  salted plum and mint tastes that their physical properties met the cough tablets criterias were weight deviation from mean < 5.0 %, percent coefficient of variation (% CV) < 2.0 %, tablet hardness > 5.5 kg, tablet friability < 1.0 % and mouth dissolving time > 30 min. The statistical principle used to test the significant difference of mean in different of tablets formulars properties were the analysis of variance (AVOVA) at p < 0.01 and lease significant difference procedure (LSD: 1.0 % allowance, α =0.01, 2-tailed) to compare the significance in the mean of nearby formulas.

          Method: From the recent entitled research “The Roles of maltrodextrin (MDX) and direct compression fillers (DCFs) in R_x development of Formulas for Prasamawaeng Cough Tablets with and without menthol I: Selection of DCFs”, qualified DCFs had Avicel^® PH - 102 and                     Dibasic Calcium Phosphate Dihydrate (DCPD) at 120 and 80 mg/tablet. Prasamawaeng tablets were developed for more 12 formulas at PVP K – 90, 3.5 % using DFC 120 and 80 mg   in 13, 15, 17, 19, 21, and 23 formulas along with MDX 80 mg/tablet and DCF 80 mg/tablet for use in 14, 16, 18, 20, 22, and 24 formulas along with MDX 120 mg/tablet, respectively. Citrus taste were 13 – 14 formulars used Avicel^® PH – 102 and 15 – 16 formulars used DCPD. Salted plum taste were 15 – 16 formulars used Avicel^® PH – 102 and 19 – 20 formulas used DCPD. And  Mint taste were 21 – 22 formulas used Avicel^® PH – 102 and 23 – 24 used DCPD, respectively.

          Results and discussion: found that 17 - 18 and 21 – 22 formulars that used Avicel^® PH - 102 in flavoring salted plum and mint taste formulas were better than 19 - 20 and 23 - 24 that used DCPD, respectively. Because they provided produced tablets met all criterias  of cough tablets and gave the % CV < 1.0 %.

          Conclusion: citrus taste coud use DCF with 2 formulas at 120 and 80 mg/tablet for making the tablets met the criterias of cough tablets. But DCPD could not be used to develop Prasamawaeng tablets with salted plum and mint taste that met criterias of cough tablets.