Acute Effects of Dynamic Handgrip Exercise on Cardio Ankle Vascular Index in Diabetes Patient
Keywords:
Arterial stiffness, cardio ankle vascular index, diabetes mellitus, dynamic handgrip exerciseAbstract
Increase arterial stiffness is associated with increased risk of coronary artery disease (CAD) and stroke. This clinical parameter could be measured by a cardio ankle vascular index (CAVI). Many exercise techniques, include aerobic and isometric handgrip exercises, have been studied to improve vascular function in vascular disease patients, which showed increase arterial stiffness during acute response, since data of dynamic handgrip exercise (DHE) effect in diabetes mellitus (DM) patients is limited. This study aims to investigate acute CAVI response to DHE in DM patients. 14 DM type 2 and 14 healthy participants were enrolled. Hemodynamics and CAVI were evaluated at rest and immediately after 3 minutes DHE. At rest, DM patients were higher in right and left CAVIs than the control. DHE significantly increased heart rate (HR), systolic blood pressure (SBP), and CAVI parameters of the DM group. The DM group exhibited larger increases of R CAVI (control vs. DM: 0.39 ± 0.48 vs. 0.78 ± 0.72, P = 0.102) and L CAVI (control vs. DM: 0.24 ± 0.50 vs. 0.78 ± 0.68, P = 0.025) post DHE. Change of time between rise of left brachial pulse wave and rise of left ankle pulse wave (ΔL tba) was greater in DM (control vs. DM: -2.64 ± 2.76 ms vs. -5.43 ± 3.84 ms, P = 0.037). DHE produced increases in HR, SBP, and CAVI as acute responses with larger CAVI changes observed in DM. This arterial stiffness response was similar to acute results by aerobic and isometric exercises.
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