Cannabinoids from Cannabis and Programmed Cell Death of Cancer Cell
Keywords:
Cancer cell, Endocannabinoid system, Phytocannabinoid, ApoptosisAbstract
Cancer is currently the number one cause of death in humans. It can be found in everyone, all sexes and ages, and in every organ of the body. The main goal of cancer treatment is to eliminate cancer cells from the body as possible by surgery, radiotherapy and chemotherapy.
This academic article presents information from various research reports about the endocannabinoid system in the body and phytocannabinoid compounds from cannabis which promote the immune system to effectively detect and force cancer cell to die by program cell death (Apoptosis). This is the control of the proliferation of cancer cells at an early stage and may be a method for prevention and treatment of cancer in combination with current therapy to be more effective to lead to a reduction in the number of patients and deaths from cancer in the future.
References
ชยันต์ พิเธียรสุนทร, แม้นมาส ชวลิต และวิเชียร จีรวงศ์ (2544). คำอธิบายตำราโอสถพระนารายณ์ฉบับเฉลิมพระเกียรติ 72 พรรษามหาราชา, 5 ธันวาคม พุทธศักราช 2542. กรุงเทพฯ: อมรินทร์.
ทะกะโฮะ วะตะโย. (2562). มะเร็งหายด้วยอาหาร [Imaaru Gan Ga Kieteku Shokuji] (ชาญ ธนประกอบ, ผู้แปล). (พิมพ์ครั้งที่ 7). กรุงเทพฯ: อินสปายร์.
ปิติ จันทร์วรโชติ. (2560). ชีววิทยาโมเลกุลของเซลล์มะเร็ง. กรุงเทพฯ: จุฬาลงกรณ์มหาวิทยาลัย.
วุฒิ วุฒิธรรมเวช. (2552). ย่อเภสัชกรรมไทยและสรรพคุณสมุนไพร. กรุงเทพมหานคร: ศิลป์สยามบรรจุภัณฑ์และการพิมพ์.
สถาบันวิจัยและพัฒนาพื้นที่สูง (องค์การมหาชน). (2562). กัญชง (เฮมพ์) กับกัญชาต่างกันอย่างไร. สืบค้นจาก https://www.hrdi.or.th/Articles/Detail/37
ศูนย์วิทยาศาสตร์เพื่อการศึกษา. (2564). กัญชง V กัญชา ความเหมือนบนความแตกต่าง. สืบค้นจาก https://sciplanet.org/content/8707
Blasco-Benito, S., Seijo-Vila, M., Caro-Villalobos, M., Tundidor, I., Andradas, C., García-Taboada, … Sánchez, C. (2018). Appraising the "entourage effect": Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer. Biochemical Pharmacology, 157, 285–293. doi.org/10.1016/j.bcp.2018.06.025
Braile, M., Marcella, S., Marone, G., Galdiero, M. R., Varricchi, G., & Loffredo, S. (2021). The Interplay between the Immune and the Endocannabinoid Systems in Cancer. Cells, 10(6), 1282. doi.org/10.3390/cells10061282
Caffarel, M. M., Sarrió, D., Palacios, J., Guzmán, M., & Sánchez, C. (2006). Delta 9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Research, 66(13), 6615–6621. doi.org/10.1158/0008-5472.CAN-05-4566
Favaloro, B., Allocati, N., Graziano, V., Di Ilio, C., & De Laurenzi, V. (2012). Role of apoptosis in disease. Aging, 4(5), 330–349. doi.org/10.18632/aging.100459
Fonseca, B. M., Correia-da-Silva, G., & Teixeira, N. A. (2018). Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis. Journal of Physiology and Biochemistry, 74(2), 261–272. doi.org/10.1007/s13105-018-0611-7
Greenhough, A., Patsos, H. A., Williams, A. C., & Paraskeva, C. (2007). The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces AD-mediated apoptosis in colorectal cancer cells. International Journal of Cancer, 121(10), 2172–2180. doi.org/10.1002/ijc.22917
Howlett, A. C., & Abood, M. E. (2017). CB1 and CB2 receptor pharmacology. Advances in Pharmacology (San Diego, Calif.), 80, 169–206. doi.org/10.1016/bs.apha.2017.03.007
Leelawat, S., Leelawat, K., Narong, S., & Matangkasombut, O. (2010). The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Cancer Investigation, 28(4), 357–363. doi.org/10.3109/07357900903405934
Ligresti, A., Moriello, A. S., Starowicz, K., Matias, I., Pisanti, S., De Petrocellis, L., … Di Marzo, V. (2006). Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. The Journal of Pharmacology and Experimental Therapeutics, 318(3), 1375–1387. doi.org/10.1124/jpet.106.105247
Patsos, H. A., Greenhough, A., Hicks, D. J., Al Kharusi, M., Collard, T. J., Lane, J. D., … Williams, A. C. (2010). The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. International Journal of Oncology, 37(1), 187–193. doi.org/10.3892/ijo_00000666
Shrivastava, A., Kuzontkoski, P. M., Groopman, J. E., & Prasad, A. (2011). Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Molecular Cancer Therapeutics, 10(7), 1161–1172. doi.org/ 10.1158/1535-7163.MCT-10-1100
Sung, H., Ferlay, J., Siegel, R; L., & et al. (2021). Global cancer statistics 2020: GLOBOCAN Estimates of incidence and mortality worldwide for 36 cancers in 185 countries. A Cancer Journal for Clinicians, 71(3), 209-249. doi:10.3322/caac.21660
Tomko, A. M., Whynot, E. G., Ellis, L. D., & Dupré, D. J. (2020). Anti-cancer potential of cannabinoids, terpenes, and flavonoids present in cannabis. Cancers, 12(7), 1985. doi.org/10.3390/cancers12071985
Turner, S. E., Williams, C. M., Iversen, L., & Whalley, B. J. (2017). Molecular pharmacology of phytocannabinoids. Progress in the chemistry of organic natural products, 103, 61–101. doi.org/10.1007/978-3-319-45541-9_3
Tutino, V., Caruso, M. G., De Nunzio, V., Lorusso, D., Veronese, N., Gigante, I., … Giannelli, G. (2019). Down-regulation of cannabinoid type 1 (CB1) receptor and its downstream signaling pathways in metastatic colorectal cancer. Cancers, 11(5), 708. doi.org/ 10.3390/cancers11050708
Zhang, X., Qin, Y., Pan, Z., Li, M., Liu, X., Chen, X., … Li, D. (2019). Cannabidiol induces cell cycle arrest and cell apoptosis in human gastric cancer SGC-7901 cells. Biomolecules, 9(8), 302. doi.org/10.3390/biom9080302
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