Application of Silver Nanoparticles in Medicine
Abstract
Nanotechnology is a multidisciplinary field; examples are food packaging materials and food supplements. In medical was an application such as diagnosis, monitoring, therapy and kill the bacteria fungi and virus.
The toxicity of nano-silver were respiratory system, skin and gastro-intestinal tract in the cellular of man and nanotechnology is the ability to work at the atomic, molecular and supra molecular levels also.
The mechanisms of silver nanoparticles the cellular responses apoptosis of cell morphology. It has been well established that dysfunction of mitochondria is a key step towards apoptosis and increased ROS was found in association with mitochondrial. However, the research of advantage and disadvantage of silver and metal nanoparticles should be further study amongst new scientists generation.
References
Cho EC, Au L, Zhang Q, Xia Y. (2010). The effects of size, shape, and surface functional group of gold nanostructures on their adsorption and internalization by cells. Small. 6(4) : 517-22.
Griffitt RJ, Luo J, Gao J, Bonzongo JC, Barber DS. (2008). Effects of particle composition and species on toxicity of metallic nanomaterials in aquatic organisms. Environ Toxicol Chem. 27(9) : 1972-8.
Kim JS, Yoon TJ, Yu KN, Kim BG, Park SJ, Kim HW. (2006). Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol Sci. 89(1) : 338-47.
Limbach L.K., Wick,P., Manser P., Grass R.N., Bruinink A., Stark W.J. (2007). Exposure of engineered nanoparticles to human lung epithelial cells: inflence of chemical composition and catalytic activity on oxidative stress. Environ. Sci. Technol. 1(41) : 4158-4163.
Lok CN, Ho CM, Chen R, He QY, Yu WY, Sun H. (2006). Proteomic analysis of the mode of antibacterial action of silver nanoparticles. J Proteome Res. 5(4) : 916-24.
Sayes CM, Reed KL, Warheit DB. (2007). Assessing toxicity of fine and nanoparticles : comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol Sci. 97(1) : 163-80.
Silver S. (2003). Bacterial silver resistance : molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev. 27(2-3) : 341-53.
Susan W.P. Wijnhoven, Willie J.G.M. Peijnenburg, Carla A. Herberts, Werner I. Hagens, Agnes G. Oomen, Evelyn H.W. Heugens. (2009). Nano-silver a review of available data and knowledge gaps in human and environmental risk assessment. Nanotoxicology. 3(2) : 109-138.
Yang ST, Fernando KA, Liu JH, Wang J, Sun HF, Liu Y. (2008). Covalently PEGylated carbon nanotubes with stealth character in vivo. Small. 4(7) : 940-4.
