Factors related to treatment adherence among people with HIV/TB co-infection
Keywords:
Treatment adherence, People with TB/HIV co-infection, Medication adherenceAbstract
Purpose: To investigate the treatment adherence and factors related to treatment adherence among people with TB/HIV co-infection.
Design: Descriptive correlational research
Methods: The sample group consisted of people who diagnosed with TB/HIV aged 20-59 years old 84 individuals from 3 tertiary hospitals in Bangkok. The research instruments demographic data, the ENRICH Social Support Questionnaire, the Alcohol Use Disorders Identification Test, knowledge about HIV/TB treatment questionnaires, the Thai Internalized HIV-related Stigma Scale brief, and Treatment Adherence Questionnaires for Patients with Hypertension. Data collection occurred from January to May 2024 at antiviral clinics during participants’ medical appointments. Data were analyzed using Pearson’s correlation and Spearman’s correlation.
Results: Treatment adherence in the sample group of 84 peoples was high (Mean = 56.23, SD = 6.218). There was a significant positive relationship between social support and treatment adherence at the level of .05 (r = .218), and a significant negative relationship between alcohol consumption and treatment adherence at the level of .05 (rs = -.311). However, no significant relationships were found between knowledge about HIV/TB treatment (r = .189), Internalized stigma (r = -.199) and treatment adherence.
Conclusion: the finding result could be serve as guidelines to develop nursing program to promote Treatment adherence in people with TB/HIV co-infection.
References
UNAIDS. The path that ends AIDS: UNAIDS Global AIDS Update 2023 [Internet]. Geneva: Joint United Nations Programme on HIV/AIDS; 2023. Available from: https://www.unaids.org/en/resources/documents/2023/global-aids-update-2023
World Health Organization. Global tuberculosis report 2023 [Internet]. (2023). Geneva: World Health Organization; 2023. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023
Division of Tuberculosis (TH). Report of Tuberculosis surveillance in 2023. Bangkok; 2023. (In Thai)
Division of Tuberculosis. Guideline of Tuberculosis control in Thailand 2021. Graphic & Design publisher; 2021. (In Thai)
World Health Organization. Adherence to long-term therapies: evidence for action [Internet]. World Health Organization; 2003. Available from: https://apps.who.int/iris/handle/10665/42682
Department of disease control. Guideline of examination treatment and protection from HIV Thailand 2021/2022. Graphic & Design publisher; 2022. (In Thai)
Rocha M, Pereira S, Ferreira L, Barros H. The role of adherence in tuberculosis HIV-positive patients treated in ambulatory regimen. European Respiratory Journal 2003; 21: 785-88.
Nhandara RBC, Ayele BT, Sigwadhi LN, Ozougwu LU, Nyasulu PS. Determinants of adherence to clinic appointments among tuberculosis and HIV co-infected individuals attending care at Helen Joseph Hospital, Johannesburg, South Africa. The Pan African Medical Journal. 2020; 37.
Isaakidis P, Rangan S, Pradhan A, Ladomirska J, Reid T, & Kielmann K. I cry every day’: experiences of patients co-infected with HIV and multidrug-resistant tuberculosis. Tropical Medicine & International Health 2013; 18: 1128-33.
Mekonnen HS, Azagew AW. Non-adherence to anti-tuberculosis treatment, reasons and associated factors among TB patients attending at Gondar town health centers, Northwest Ethiopia. BMC Research Notes 2018; 11.
Martiana I, Waluyo A, Yona S. Assessing the relationship between knowledge of antiretroviral therapy and stigma regarding adherence to ART among men who have sex with men. Enfermeria Clinica 2019; 29: 321-325.
Ma C, Chen S, You L, Luo Z, Xing C. Development and psychometric evaluation of the Treatment Adherence Questionnaire for Patients with Hypertension. Journal of Advanced Nursing. 2012; 68:1402-13.
Krethong P. A casual model of health-related quality of life in thai heart failure patients [dissertation]. Bangkok: Chulalongkorn University; 2007. (In Thai)
World Health Organization. AUDIT: the alcohol use disorders identification test guideline for primary care 2nd edition. Thantawan paper inc.; 2001. (In Thai)
Jittimanee SX, Nateniyom S, Kittikraisak W, Burapat C, Akksilp S, et al. Social Stigma and Knowledge of Tuberculosis and HIV among Patients with Both Diseases in Thailand. PLOS ONE. 2009; 4.
Uthis P, Suktrakul S, Wiwatwongwana R, Tangmunkongvorakul A, Sripan P, Srithanaviboonchai K. The Thai Internalized HIV-related Stigma Scale. Frontiers in psychology 2023; 14.
Rynhoud L, Kagee A. Prevalence of alcohol and drug use and their impact on adherence among hospitalised TB patients in South Africa. Journal of health psychology 2024.
Yunita EP, Wardani RNK, Sidharta B. Correlation between knowledge level, side effect severity, family support, and antiretroviral therapy adherence in HIV/AIDS patients in Greater Malang, East Java, Indonesia. Pharmacia 2023; 70: 1213-22.
Appalarouthu N, Sirivella A, Othuri SVS. Impact of Stigma and Level of Education on Adherence to Treatment with Both TB and HIV/AIDS in Tertiary Care Teaching Hospital, Andhra Pradesh: A Retrospective Observational Study. European Journal of Medical and Health Sciences 2023; 5: 74-8.
Kipp AM, Pungrassami P, Stewart PW, Chongsuvivatwong V, Strauss RP, Van RA. Study of tuberculosis and AIDS stigma as barriers to tuberculosis treatment adherence using validated stigma scales. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2011; 15: 1540-51.
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